Методики

AutoDest and AutoDry function with SyncorePlus

AutoDest and AutoDry are two possibilities making evaporations on the SyncorePlus even more convenient without a need to define a method.

This Technical Note revealed that the AutoDest and AutoDry option have an excellence performance with a SyncorePlus system. The automated evaporation of different solvents were investigated on SyncorePlus Polyvap and SyncorePlus Analyst by use of the AutoDest sensor in combination with the AutoDry valve without a preset method.

Ammonium, nitrate, and total nitrogen determination in fly ash

Fly-ash is a by-product of the combustion of pulverized coal and is composed of small particles. Nowadays, air pollution control standards require a separation of flue gas before being released to the atmosphere.The composition of the fly ash may vary considerabley, however, all fly ashed contain substantial amounts of silicon dioxide (SiO2) aluminium oxide (Al2O3) and calcium oxide (CaO). The fly ash in this study was provided from a pulp mill containing organic and inorganic (ammonium nitrate and ammonium sulfate) nitrogen compounds.

Spray Drying of Ammonium chloride

Ammonium chloride is a chemical compound commonly used in various industries, including pharmaceuticals, agriculture, and food processing. Spray drying is a technique that has been explored for the production of ammonium chloride powder, offering advantages such as improved handling, storage stability, and controlled release.

The areas of focus in spray drying of ammonium chloride include optimizing the process parameters, such as the inlet and outlet temperatures, atomizer type, and feed rate, to achieve the desired particle size, morphology, and flow properties of the powder. Additionally, research has been conducted to evaluate the impact of different additives and excipients on the physical and chemical properties of the powder, such as its solubility, caking tendency, and moisture absorption.

Furthermore, spray drying has been investigated as a method for producing ammonium chloride particles with tailored properties, such as controlled release or improved dissolution rate, for specific applications. For instance, in the agriculture industry, spray-dried ammonium chloride formulations can offer slow and controlled nutrient release for fertilizers. In pharmaceutical applications, spray-dried ammonium chloride powders can be used in inhalable formulations for respiratory conditions. Overall, spray drying of ammonium chloride provides a promising approach for enhancing the functionality and performance of this compound in various industries.

Please see the application note No. 430 for starting parameters, formulations and some results.

Spray Drying of Vanillin

Vanillin is a widely used flavoring agent that is commonly found in foods, beverages, and cosmetics. Spray drying is a popular method for producing vanillin powder, which can be easily incorporated into various products. The process involves atomizing a vanillin solution or suspension into a spray of fine droplets, which are then dried by hot air.

Spray drying of vanillin offers several advantages, including improved shelf life, increased solubility, and enhanced flavor stability. The resulting powder is also easier to handle and transport compared to the liquid form.

The quality of the vanillin powder produced by spray drying can be optimized by adjusting the process parameters, such as the inlet temperature, feed rate, and drying air flow rate. This allows for the production of vanillin powder with different particle sizes, densities, and moisture contents.

Overall, spray drying is a cost-effective and efficient method for producing high-quality vanillin powder that can be used in a variety of applications, including food and beverage manufacturing, cosmetics, and pharmaceuticals.

Please find starting parameters and some Results in this Application Note No. 710.

Spray Drying of Watermelon juice

Watermelon juice is a popular beverage that is rich in nutrients and antioxidants. Spray drying is a commonly used method for producing watermelon juice powder, which can be easily stored and transported, and has a longer shelf life compared to the liquid form.

The process of spray drying watermelon juice involves atomizing the juice into a spray of fine droplets, which are then dried by hot air. The resulting powder is free-flowing, and retains the flavor and nutritional value of the original juice.

Spray drying of watermelon juice offers several advantages, including improved product stability, ease of handling, and reduced storage and transportation costs. The process parameters can be optimized to control the particle size, density, and moisture content of the resulting powder, which can be tailored to meet specific product requirements.

Overall, spray drying is a cost-effective and efficient method for producing high-quality watermelon juice powder that can be used in various applications, including food and beverage manufacturing, dietary supplements, and cosmetics.

Please find starting parameters and some Results in this Application Note No. 714.

Spray Drying of Cellulose

Целлюлоза - это природный полимер, обнаруживаемый в клеточных стенах растений, и широко используется в различных отраслях, включая пищевую, фармацевтическую и косметическую. Спрей-сушка - это техника, которая может быть использована для превращения целлюлозы в сухой порошок, что может иметь преимущества для различных применений, таких как доставка лекарств, обработка пищевых продуктов и покрытия.

Области фокуса в спрей-сушке целлюлозы включают оптимизацию параметров процесса, таких как температура на входе, температура на выходе, тип атомизатора, скорость подачи и состав растворителя, чтобы достичь желаемого размера частиц, морфологии и чистоты порошка целлюлозы. Кроме того, проводятся исследования для оценки воздействия различных вспомогательных веществ и эксипиентов на физические и химические свойства порошка целлюлозы, такие как ее растворимость, способность к увлажнению и реологическое поведение.

Другие интересующие области включают разработку новых целлюлозных материалов с уникальными свойствами, такими как высокая пористость или способности контролируемого высвобождения, для различных применений, таких как доставка лекарств или тканевая инженерия. Спрей-сушка также исследуется как потенциальный метод для производства целлюлозных порошков с настроенными функциональными свойствами, такими как улучшенная адгезия или барьерные свойства. В целом, спрей-сушка целлюлозы представляет собой многообещающий подход для улучшения функциональности и производительности целлюлозных материалов в различных применениях.

Пожалуйста, обратитесь к примечанию к приложению для начальных параметров, формул и некоторых результатов.

Spray Drying of Cell suspension (anaerobe enterobacteria)

Анаэробные энтеробактерии представляют собой тип бактерий, способных вызывать ряд инфекций у человека, таких как инфекции желудочно-кишечного тракта, инфекции мочевыводящих путей и сепсис. Клеточная суспензия представляет собой метод, используемый для культивирования и поддержания этих бактерий в жидкой среде, которую затем можно использовать для различных исследовательских или диагностических целей. Рассеивание суспензии - это техника, которая может использоваться для превращения жидкой клеточной суспензии в сухой порошок, что может иметь преимущества для хранения, транспортировки и подготовки бактериального образца. Области фокуса в рассеивании суспензии анаэробных энтеробактерий включают оптимизацию параметров процесса, таких как температура на входе, температура на выходе, тип атомизатора, скорость подачи и состав растворителя, для достижения желаемого размера частиц, морфологии и жизнеспособности бактерий. Кроме того, проводились исследования для оценки влияния различных условий сушки на выживаемость и генетическую стабильность бактериального образца, а также его антигенность и иммуногенность. Другие области интереса включают разработку новых формуляций и систем доставки для бактериального порошка, таких как вакцины или пробиотики, которые могут улучшить их эффективность и безопасность. Рассеивание суспензии также исследовалось как потенциальный метод для производства бактериальных порошков с настроенными функциональными свойствами, такими как улучшенная адгезия или способность к колонизации. В целом, рассеивание суспензии клеток анаэробных энтеробактерий представляет собой многообещающий подход к улучшению диагностики и лечения бактериальных инфекций. Пожалуйста, ознакомьтесь с приложением для начальных параметров, формуляций и некоторых результатов.

Spray Drying of Tungsten oxide / Tantalum oxide

Spray drying has been used to produce tungsten oxide/tantalum oxide composite powders with tailored properties for various applications. Tungsten oxide and tantalum oxide are both wide-bandgap semiconductors that exhibit excellent electrical and optical properties.

The spray drying process involves atomizing a suspension or solution of tungsten and tantalum precursors into a spray of fine droplets, which are then dried by hot air to form a dry powder. The resulting powder can be characterized by its particle size, morphology, and chemical composition.

Spray drying of tungsten oxide/tantalum oxide composites offers several advantages, including improved product homogeneity, enhanced process efficiency, and reduced manufacturing costs. The process parameters can be optimized to control the particle size distribution, morphology, and chemical composition of the resulting powder, which can be tailored to meet specific product requirements.

Overall, spray drying is a promising method for producing high-quality tungsten oxide/tantalum oxide composite powders that can be used in a variety of applications, such as electrochromic devices, energy storage, and catalysts.

Please find starting parameters and some Results in this Application Note No. 706.

Spray Drying of Vitamins

Spray drying is a popular method for producing dry powders of vitamins, which are commonly used in food, beverage, and dietary supplement formulations. The process involves atomizing a liquid vitamin solution or suspension into a spray of fine droplets, which are then dried by hot air.

Spray drying of vitamins offers several advantages, including improved shelf life, increased stability, and enhanced bioavailability. The resulting powder is also easier to handle and transport compared to the liquid form.

The quality of the vitamin powder produced by spray drying can be optimized by adjusting the process parameters, such as the inlet temperature, feed rate, and drying air flow rate. This allows for the production of vitamin powders with different particle sizes, densities, and moisture contents.

Overall, spray drying is a cost-effective and efficient method for producing high-quality vitamin powders that can be used in various applications, including fortification of foods and beverages, dietary supplements, and pharmaceuticals.

Please find starting parameters and some Results in this Application Note No. 712.

Spray Drying of Tuberculosis vaccine

Spray drying has been investigated as a method for producing a stable and effective tuberculosis vaccine. The tuberculosis vaccine, also known as Bacille Calmette-Guérin (BCG), is a live attenuated vaccine that is currently the only vaccine available for preventing tuberculosis. However, BCG has several limitations, including its variability in efficacy and stability.

The spray drying process involves atomizing a BCG vaccine solution into a spray of fine droplets, which are dried by hot air to produce a dry powder. The resulting powder is stable at room temperature and can be stored for extended periods without losing its efficacy.

Spray drying of tuberculosis vaccine offers several advantages, including improved stability, enhanced product uniformity, and reduced manufacturing costs. The process parameters can be optimized to control the particle size, morphology, and chemical composition of the resulting powder, which can be tailored to meet specific product requirements.

Overall, spray drying is a promising method for producing a stable and effective tuberculosis vaccine that can be used in various global health initiatives.

Please find starting parameters and some Results in this Application Note No. 704.

Spray Drying of Titanium carbide

Spray drying is a popular method for the production of nanoparticles and powders with uniform size, shape, and composition. One of the materials that can be produced through spray drying is titanium carbide, a hard ceramic material with high thermal stability, excellent electrical conductivity, and high hardness. The production of titanium carbide nanoparticles through spray drying involves the formation of a stable suspension of the precursor in a solvent, followed by atomization and drying of the droplets in a hot gas stream.

The key parameters that influence the quality of the final product include the composition of the precursor, the solvent used, the drying temperature, and the gas flow rate. A well-optimized process can lead to the production of titanium carbide nanoparticles with a narrow size distribution and high purity. These nanoparticles can find applications in various fields such as energy storage, catalysis, and biomedical engineering.

Please find starting parameters and some Results in this Application Note No. 696.

Spray Drying of Tenside (Surfactants)

Spray drying of tensides involves the conversion of liquid tenside formulations into powders. Tensides, also known as surfactants, are chemical compounds that are commonly used in a variety of industrial and consumer products, including detergents, cleaners, and personal care products. The spray drying process is used to create a dry powder form of the tenside, which can be easily stored and transported.

During spray drying, the liquid tenside formulation is atomized into small droplets that are then dried in a hot gas stream. The resulting powder is typically free-flowing and has a high bulk density, making it easier to handle and process. Spray drying can also improve the stability and shelf-life of the tenside powder.

The spray drying process parameters, such as inlet temperature, atomization pressure, and airflow rate, can be optimized to produce a powder with desired properties such as particle size, morphology, and flowability. Additionally, the use of encapsulation techniques in spray drying can further enhance the stability and performance of the tenside powder.

Please find starting parameters and some Results in this Application Note No. 691.

Technical note on carry-over and cross-contamination

Из образцов отложений и почвы, содержащих ПАУ, ПХД, диоксины и фураны, экстрагировались загрязнители с помощью SpeedExtractor E-916. Во время работы прибора анализировались параллельные холостые пробы (для определения перекрестного загрязнения) и последовательные холостые пробы (для определения переноса загрязнений от пробы к пробе) на предмет возможного перекрестного загрязнения или переноса загрязнений. В результате, не наблюдалось ни перекрестного загрязнения, ни переноса загрязнений от пробы к пробе. SpeedExtractors показал превосходную надежность в обоих аспектах.

Spray Drying of Theophiline

Theophylline is a medication commonly used to treat respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Spray drying is one of the methods used to prepare theophylline for oral administration. This process involves the conversion of theophylline powder into a fine spray-dried powder that is more easily absorbed by the body.

The spray-drying process involves the atomization of theophylline solution into droplets, which are then dried by a stream of hot air, resulting in the formation of a fine powder. The properties of the spray-dried theophylline powder, such as particle size, morphology, and crystallinity, are affected by several factors, including the drying temperature, feed rate, and solution concentration.

The spray-dried theophylline powder has improved flowability, dissolution rate, and bioavailability compared to theophylline powder obtained through other methods. The spray-drying method is also scalable, making it a feasible method for the large-scale production of theophylline powder for oral administration.

Please find starting parameters and some Results in this Application Note No. 694.

Total fat determination in meat products according to Weibull-Stoldt method

A simple and reliable procedure for fat determination of meat products according to Weibull-Stoldt is introduced. The sample is hydrolyzed with the HydrolEx H-506. The Soxhlet extraction is performed with the FatExtractor E-500. Calculation of total fat content follows gravimetrically after the extract has been dried to a constant weight. This application follows official methods (eg. EN 98/64/EG, AOAC 963.15, ISO 1443:1973). The combination of the new HydrolEx H-506 and the FatExtractor E-500 increases the sample throughput.

Spray Drying of Tobramycin

Tobramycin is an antibiotic used to treat various bacterial infections, including respiratory tract infections and infections in people with cystic fibrosis. Spray drying is a commonly used method to prepare tobramycin powder formulations for inhalation therapy.

Spray drying involves atomizing a solution of tobramycin in a solvent into a fine mist, which is then dried rapidly in a stream of hot air. The resulting dry powder is composed of small, spherical particles with controlled size and morphology.

The properties of the tobramycin powder produced by spray drying can be optimized by adjusting various process parameters such as inlet temperature, feed rate, and drying time. The use of various excipients or drying aids can also affect the properties of the final powder.

Overall, spray drying is a highly effective method for producing tobramycin powders with optimal properties for inhalation therapy. The process allows for the production of a high quantity of uniform particles with excellent flowability and dispersion properties, which can enhance the delivery and efficacy of the drug.

Please find starting parameters and some Results in this Application Note No. 699.

Total SO2 content determination in shrimp paste by modified Monnier-Williams Method

Total SO2 is defined as “the total of all the various forms of sulfur dioxide present in the sample, either in the free state or combined with their constituents”. Its determination in solid samples poses a challenge because SO2 is withheld in adducts and is released slowly during boiling. Recognized results are obtained by means of the generally accepted Optimized Monier-Williams method according to AOAC 990.28 which suggests the use of nitrogen-assisted boiling of the acidified sample to release the Total SO2. The method presented in this study provides equally quantitative results with much less time required per sample and is based on steam distillation followed by pH titration.

In this application note No. 791/2022 recovery results for a widely used reference standard HMS, and a certified sample of shrimp paste (41±9.7ppm) for total sulfite analysis are presented. A representative concentration of 1 mg SO2 /sample tube is selected to demonstrate the robust performance of modified Monier-Williams method by steam distillation. 

Spray Drying of Tofu

Spray drying has been proposed as an effective way to convert tofu into a powder form that can be used as a food ingredient. Tofu is a soybean-based product that is rich in protein and contains essential amino acids, vitamins, and minerals. The spray drying process involves converting tofu into a liquid form, which is then atomized into droplets and dried in a heated chamber. This process can help to extend the shelf life of tofu and make it easier to transport and store.

The spray drying of tofu has been studied in terms of the effects of process parameters on the quality of the final product. For example, it has been found that the drying temperature, feed concentration, and atomization pressure can all impact the protein content, solubility, and morphology of the resulting tofu powder. Overall, spray drying has shown promise as a way to transform tofu into a more versatile and convenient ingredient for food production.

Please find starting parameters and some Results in this Application Note.

TKN determination in water and wastewater

An easy and reliable method for the determination of Total Kjeldahl Nitrogen (TKN) in water and wastewater, according to ISO 5663, DIN EN 25 663 and the methods listed in 40 CFR part 136.3, is introduced below. In this study, the limit of detection (LOD) and limit of quantification (LOQ) which is a measure of sentisivity of a method, were determined. To test the performance, nitrogen recovery in different concentrations of urea solutions was tested. The samples are digested using the SpeedDigester K-439 using Kjeldahl Tablets Titanium. A steam distillation protocol followed bya suitable boric acid titration is performed with the MultiKjel together with the Metrohm Eco Titrator. Coupling the new MultiKjel system and the Eco Titrator results in excellent performance with ease and speed of the analysis.

Total SO2 content determination in reference standards by BUCHI method

Sulfites are widely used as preservatives and antioxidants in foods and beverages. Exposure to high levels of sulfites can cause an allergic reaction. Given the health risks associated with sulfite exposure, its amount in beverages and foods is regulated in many countries. Regulations have set the maximum amount of sulfites used and required labelling practice to indicate the presence of sulfites. Total SO2 is defined as “the total of all the various forms of sulfur dioxide present in the sample, either in the free state or combined with their constituents”. Its determination in solid samples poses a challenge because SO2 is withheld in adducts and is released slowly during boiling. Recognized results are obtained by means of the generally accepted Optimized Monier-William’s method according to AOAC 990.28 which suggests the use of nitrogen-assisted boiling of the acidified sample to release the Total SO2. The method presented in this study provides equally quantitative results with much less time required per sample and is based on the patented BUCHI Method that involves steam distillation followed by a redox titration.