Lyovapor™ L-300

First lab Freeze Dryer for continuous sublimation

With Infinite-Technology™, the Lyovapor™ L-300 is the first lab freeze dryer for continuous sublimation thanks to two alternately working condensers that are automatically cleaned. In addition, control the entire process remotely via mobile devices.

  • Condenser capacity:Unlimited
  • Condensing capacity:≤ 12 kg / 24 h
  • Lowest condenser temperature:-105°C
Lyovapor™ L-300

Continuous sublimation

The most exciting feature of the Lyovapor™ L-300 is its infinite ice capacity made possible by alternate condenser loading. For the first time, you can perform continuous sublimation thanks to stable, reproducible parameters including cooling temperature, shelf temperatature variation ±1 °C, as well as vacuum pressure with Smart-Switch.

Continuous sublimation


Benefit from maximal freeze-drying flexibility. Use various drying chamber options that are suited to your individual application. Install and operate the Lyovapor™ L-300 from any location or in a fume hood. An optional upgrade to Interface Pro offers you even more versatility in customizing your freeze-drying process.



The Lyovapor™ L-300, as the first lab freeze dryer for continuous sublimation, offers exceptionally stable process parameters incl. cooling temperature, shelf temperature variation ±1 °C and vacuum pressure. 

Plus, as a Lyovapor™ L-300 user, you can use the endpoint determination feature to fully optimize your process. 



  • Optimize your process by combining temperature difference with optional product temperature sensors for reliable endpoint determination.

    End point determination
  • An integrated steam generator melts the ice and cleans the condenser hygienically.

    Automated Cleaning
  • Easily read process parameters thanks to an adjustable display that can be placed at the front or on the side of the freeze dryer.

    Ergonomic handling
  • Adjust the shelf distance to suit your application needs. Link three manifold racks together for more versatility in your freeze-drying process.

    Flexible drying chambers
  • The combination of interface, software and a user-friendly app enables you to continuously control and monitor your freeze-drying process from anywhere at any time.

  • Take advantage of the most advanced features of Lyovapor™ L-300 with the Lyovapor™ Software and a simple upgrade to Interface Pro.

"The Lyovapor™ L-300 is the highly automated freeze dryer with continuous defrosting and 36 manifold positions providing less instrument downtime. The usage in the laboratory with open access and in small molecule synthesis with high sample throughput are the key features for high productivity."David Wechsler - Medicinal Chemistry, Roche Pharma Research and Early Development, Basel


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From standard application to unlimited ice capacity

BUCHI has been producing user-friendly and highly beneficial solutions in the area of laboratory evaporation for more than 55 years. Those decades of experience and high quality demands feed directly into innovative solutions for Freeze Drying. For the first time, continuous Freeze Drying is available to a broad spectrum of applications from research and development to quality control in a wide variety of market segments.
  • Education

    For a wide range of applications in academic education: Complete temperature sensitive drying.

  • Biotechnology

    Used in biotechnology development for drying biologically active products: Drying and stabilization of small quantities in micro titer plates or small flasks.

  • Environmental Analysis

    Required for sample preparation and stabilization to monitor environmental pollution: During storage of samples in order to destroy micro-organisms. Drying, e.g. for SpeedExtractor.

    Environmental Analysis
  • Chemical

    For gentle and lossless drying in QC and R&D laboratories: Drying of most minute quantities in micro titer plates as well as small and large flasks or bulk drying is possible.

  • Food and Natural Extracts

    Used for developing function-al food and analytics: Solvent is removed during, drying without destroying, the natural substances such as proteins, minerals or vitamins.

    Food and Natural Extracts
  • Pharmaceutical

    For various applications in QC as well as laboratory scale synthesis and formulation in R&D departments: Drying of peptides and proteins of amorphous and crystalline solutions.