Lyovapor™ L-250

Maximize sustainability and freeze-drying efficiency with EcoStream™

Introducing the Lyovapor™ L-250, featuring our groundbreaking EcoStream™ technology: the most eco-friendly freeze-drying solution for your laboratory. Our innovative cooling technology significantly lowers the environmental impact of the instrument without compromising our commitment to quality and reliability. The L-250 embodies BUCHI’s commitment to enhancing the sustainability of laboratory processes worldwide.

  • Lowest condenser temperature:-85°C
  • Condenser capacity:≤ 5 kg
  • Condensing capacity:≤ 4 kg / 24 h
  • GWP index:4
Lyovapor™ L-250

EcoStream™ Innovation

Our innovative compressor design enables the condenser to reach temperatures as low as -85°C.

Features a low Global Warming Potential (GWP) rating of just 4 with natural coolants, reducing the environmental impact

Lower the amount of heat output and noise emissions in your lab

EcoStream™ Innovation

Save energy, enhance performance

Profit from reduced electrical energy consumption due to the smart design of our compressor.

Achieve an ice condenser capacity of 4 kg /24 h, with a total capacity of 5 kg.

The stable ice condenser temperature allows for the efficient collection of water and organic-based solvents.

Save energy, enhance performance

Embrace efficiency and elevate control

Featuring Infinite-Control™ technology that offers unprecedented levels of process control via display, software, and mobile app.

Benefit from sample protective state and endpoint determination for a safe and short freeze drying run.

Easy installation on a bench, trolley, or fume hood.

Embrace efficiency and elevate control


  • Several drying chambers accommodate a wide range of applications. Unheated and heated shelves in combination with manifold, plain and stoppering cover as well as manifold rack with 12 to 24 connections. 


    Modularity meets flexibility
  • Easily dry both liquid and solid materials in flasks and trays. The stable ice condenser temperature ensures complete solvent collection, even for large sample quantities, complemented by precise endpoint determination.

    Basic Instrument
  • Offers advanced drying capabilities in vials and trays. Achieve precise control of residual moisture and faster drying times. This instrument allows customized method programming, ensuring enhanced sample integrity and the highest level of reproducibility. Additionally, it features a robust heating shelf.

    Pro Instrument
  • Endpoint determination using pressure and temperature difference tests for heated shelf applications and processes on a manifold steel drying rack. 

    Process analytics
  • The pro version features a sample protective state that automatically activates if the sample temperature rises above the set collapse temperature, offering peace of mind by safeguarding precious samples.

    Sample protection mode
  • The system provides a real-time graphical display of key process parameters, including drying chamber pressure, sample temperature, and shelf temperature. These can be monitored directly through the interface as well as via an app and accompanying software.

    Process monitoring
  • Experience comprehensive data management tools, allowing for detailed analysis and evaluation of recorded data as well as customized reports. Designed for user-friendly operation, it allows you to conveniently create and start methods right from your desk.

    Enhance your process with Lyovapor™ software

Compare the Lyovapor™ L-250

  • Lyovapor™ L-250 Basic

    • Lowest condenser temperature:-85 °C
    • Condensing capacity at 25°C ambient temperature:4 kg
    • Drying chamber:Manifold, unheatable shelves
    • Advanced vacuum control:Yes
    • Ultimate vacuum (no control):Yes
    • Endpoint determination:Via Pressure
    • Touch screen size:4.6 in
    • Drying shelf temperature:-
    • Stoppering:Optional
    • Product temperature sensor:-
  • Lyovapor™ L-250 Pro

    • Lowest condenser temperature:-85 °C
    • Condensing capacity at 25°C ambient temperature:4 kg
    • Drying chamber:Heatable shelves
    • Advanced vacuum control:Yes
    • Ultimate vacuum (no control):No
    • Endpoint determination:Via Pressure, Temperature
    • Touch screen size:4.6 in
    • Drying shelf temperature:Up to 60 ± 1°C
    • Stoppering:Optional
    • Product temperature sensor:Optional


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From standard application to unlimited ice capacity

BUCHI has been producing user-friendly and highly beneficial solutions in the area of laboratory evaporation for more than 55 years. Those decades of experience and high quality demands feed directly into innovative solutions for Freeze Drying. For the first time, continuous Freeze Drying is available to a broad spectrum of applications from research and development to quality control in a wide variety of market segments.
  • Education

    For a wide range of applications in academic education: Complete temperature sensitive drying.

  • Biotechnology

    Used in biotechnology development for drying biologically active products: Drying and stabilization of small quantities in micro titer plates or small flasks.

  • Environmental Analysis

    Required for sample preparation and stabilization to monitor environmental pollution: During storage of samples in order to destroy micro-organisms. Drying, e.g. for SpeedExtractor.

    Environmental Analysis
  • Chemical

    For gentle and lossless drying in QC and R&D laboratories: Drying of most minute quantities in micro titer plates as well as small and large flasks or bulk drying is possible.

  • Food and Natural Extracts

    Used for developing function-al food and analytics: Solvent is removed during, drying without destroying, the natural substances such as proteins, minerals or vitamins.

    Food and Natural Extracts
  • Pharmaceutical

    For various applications in QC as well as laboratory scale synthesis and formulation in R&D departments: Drying of peptides and proteins of amorphous and crystalline solutions.