Spray Drying of Gentamicin
Gentamicin is an aminoglycoside antibiotic that is commonly used to treat bacterial infections. Spray drying is a promising technique used to produce dry powder formulations of gentamicin, which can improve the stability and bioavailability of the drug.
Spray drying of gentamicin requires careful optimization of several parameters, such as the type and concentration of the excipient, the drying temperature, and the feed rate. The final powder properties such as particle size, morphology, and gentamicin stability depend on these parameters.
The applications of spray-dried gentamicin powder are diverse and include the production of inhalable powders, injectable powders, and topical powders. The use of spray-dried gentamicin powder can reduce the dosage and toxicity of the drug, improve patient compliance, and provide targeted drug delivery.
Overall, spray drying of gentamicin powder is an important process in the pharmaceutical field, providing a versatile and stable powder form with improved drug delivery properties.
Please see the application note No. 524 for starting parameters, formulations and some results.
