Lyophilisation of mannitol and NaCl solutions in serum vials
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
Registrati
Strumenti correlati
Lyovapor L-200
Essendo il primo liofilizzatore con Infinite-Control™, il compatto Lyovapor L-200 offre un'automazione senza precedenti nella sublimazione. Consente di creare ed eseguire facilmente metodi, registrare dati, registrare grafici in tempo reale e interagire da qualsiasi luogo e in qualsiasi momento da dispositivi mobili.
Lyovapor L-300
Con Infinite-Technology™, Lyovapor™ L-300 è il primo liofilizzatore da laboratorio per la sublimazione continua grazie a due condensatori che lavorano alternativamente puliti automaticamente. Inoltre, controlla l'intero processo da remoto tramite dispositivi mobili.
