Lyophilisation of mannitol and NaCl solutions in serum vials
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
Registration für Download
Weitere Instrumente
Lyovapor L-200
Als erster Gefriertrockner mit Infinite-Control™ bietet der kompakte Lyovapor L-200 unvergleichliche Automatisierung der Sublimation. Er ermüglicht Methoden- und Protokolldatenerstellung und -ausführung, Datenprotokollierung, Diagrammaufzeichnungen in Echtzeit sowie Benutzereingriffe per Mobilgerät von jedem Ort aus und zu jedem Zeitpunkt.
Lyovapor L-300
Die Infinite-Technology™ macht den Lyovapor™ L-300 zum ersten Labor-Gefriertrockner für die kontinuierliche Sublimation, dank zweier alternierender Kühler mit automatischer Reinigung. Ausserdem ist der gesamte Prozess über Mobilgeräte fernsteuerbar.
