Lyophilisation of mannitol and NaCl solutions in serum vials
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
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Instruments correspondants
Lyophylisateur L-200
Premier lyophilisateur doté d'Infinite-Control™, le L-200 compact offre une automatisation inégalée en matière de sublimation. Créez et exécutez facilement des méthodes, consignez des données, enregistrez des graphiques en temps réel et interagissez où que vous soyez à l'aide de vos appareils mobiles.
Lyophylisateur L-300
Doté de la technologie "Infinite", le L-300 est le premier lyophilisateur de laboratoire permettant une sublimation continue grâce à deux condenseurs fonctionnant en alternance et nettoyés automatiquement. Vous pouvez également contrôler l'ensemble du processus à distance via des appareils mobiles.
