Applications: Freeze Dryers

Freeze drying of Pharmaceutical Ingredients

BUCHI Lyovapor™ L-250 Basic is applied in freeze drying active pharmaceutical compounds dissolved in organic solvent mixtures.

Polycyclic aromatic hydrocarbons in sludge samples

Lyovapor™ L-210 Pro, SpeedExtractor E-916, Syncore Analyst: Pressurized Solvent Extraction of a sludge sample for the determination of polycyclic aromatic hydrocarbons (PAHs)

Lyophilisation of Traditional Chinese Medicine decoctions

Traditional Chinese Medicines (TCM) are usually prepared by mashing and boiling in water. This process is called decoction. Thereby, health beneficial compounds are extracted from herbal and plant material. If not directly administered, these extracts can be preserved for a longer shelf life using lyophilisation. In this Short Note we highlight the lyophilisation procedure of Tianma Gouteng Yin (TGY), as a TCM model decoction. TGY is a widely used medicine applied to treat Parkinson’s disease (PD) like symptoms. Recently, it has been reported that this TCM decoction exerts neuroprotective effects in animal and cell models of PD.

Lyophilisation of strawberries

Lyovapor™ L-200: Freeze Drying of strawberries

We developed a freeze-drying method with optimized process time and residual moisture content for strawberries.

Endpoint of freeze drying by pressure difference test

The pressure difference test in manifold drying chamber on Lyovapor™ is used to determine the end of the primary drying phase. A range of water-solvent mixtures is analyzed to identify conditions enabling reliable implementation for this test.

Extraction of micropollutants from contaminated sediments after heavy rain events

Pressurized solvent extraction (PSE) of contamined sediments as a critical part of aquatic risk accessment

End point determination for a manifold set up in L-300

End point determination for a manifold set up in Lyovapor™ L-300 Pro by pressure difference test and pressure rise test

Lyophilization of Giloy stem

In traditional Indian medicine, Giloy is one of the most useful ayurvedic herb. Freeze drying is evaluated as a drying method in order to preserve Giloy properties. Freeze drying is known to be one of the most appropriate method for the preservation of natural and biological materials thanks to the oxygen free environment and the low operating temperatures.

Lyophilisation of fresh banana slices

Lyophilisation of truffles

Lyophilisation of mannitol and NaCl solutions in serum vials

Lyophilisation of apples

Lyovapor™ L-210: Freeze Drying of apples

We developed a freeze-drying method with optimized process time and residual moisture content for apples.

Determination of Polycyclic Aromatic Hydrocarbons in water using SyncorePlus with Solid Phase Extraction (SPE) cover

SyncorePlus Analyst: 

Determination of Polycyclic Aromatic Hydrocarbons in water using SyncorePlus with Solid Phase Extraction (SPE) cover

The use of organic solvents in laboratory freeze-dryer

Freeze-dryers were initially intended to be used with water as a solvent. With new applications, freeze-drying is consequently being used more and more in combination with organic solvents instead of water. Organic solvents and inorganic acids and bases are often used in research and development prior to lyophilisation of the sample. The behavior of these new types of samples during freeze-drying must therefore be considered prior to the process.

Freeze Drying Adviser Vol.1: Basic theory & applications

This guide provides you with basic knowledge and applications for Freeze Drying

Formulation adviser for cannabis oil samples

With this free whitepaper, gain useful insights into spray drying and encapsulation, two common techniques used to formulate cannabinoids. Plus, learn about why we need cannabinoids in powder form in the first place.

Use the guide to easily achieve a sellable form of cannabinoids.  

Freeze Drying Adviser Vol.2: Illustrated toolkit for general users

This guide provides you with knowledge about hardware, the freeze-drying process, overview of the most important parameters and steps in sample preparation.

Stay ahead of your freeze drying time! – Poster

Stick the lyophilization poster to your wall! Download your free poster now – "Stay ahead of your freeze drying time!"

Automatic freeze drying endpoint determination for vials application

Automatic freeze drying endpoint determination for vials application on Lyovapor™ L-300 Pro by pressure difference test, pressure rise test and temperature difference test