Pure Excellence Chromatography System

Effortless solutions for high-performance purification.

The Pure Excellence Chromatography systems allow you to select the most powerful instrument for your specific purification application. Designed with users in mind, the C-905, C-910, and C-915 models provide the most powerful flash chromatography capabilities and flexible detection options, including ELSD, while the C-950 also integrates prep HPLC for greater versatility.

  • Detection:UV and ELSD
  • Pump:Flash and prep HPLC mode
  • System Design:Compact and fully automated
Pure Excellence Chromatography System

Effortless user experience

A focus on user-centric design ensures that each feature enhances your workflow and simplifies operations. Every detail, from intuitive software to innovative hardware, is crafted to reduce hassle and increase efficiency.

Unparalleled purity

Achieve high-performance purification, even when handling the most complex samples. With market-leading pressure limits, ELS detection, and flexible solvent combinations, the systems ensure unmatched efficiency and reliability in purification workflows.

Enhanced safety and security

Safety is the cornerstone of the Pure Excellence Chromatography systems. Advanced sensors continuously monitor critical parameters while innovative features minimize risk and achieve high-performance purification with absolute confidence.

Features

  • The innovative cartridge holder lets you connect the flash cartridge with only one hand, locking it in place and preventing disconnection during runs. The universal Luer connections are compatible with any flash cartridge on the market, eliminating the need for adapters.

  • The ELSD with its patented direct nano-pulse injection ensures that no valve, transfer line, or make-up pump is required for sample transport. This also means that almost no spare parts or maintenance are required. Additionally, the ELSD features the smallest sample loss on the market (30 μL/min). 

  • Our pumps feature a three-piston design for pulse-free flow and high-quality separation. The prep HPLC pump handles up to 400 bar at 150 mL/min, and the flash pump supports up to 50 bar at 300 mL/min, which is in line with the current trend using flash cartridges filled with small silica particle sizes.

  • With its innovative design and powerful functionality, the software enables effortless and efficient run configuration with minimal learning required. The interface was built to focus on the chromatogram across different screens, while specialized features maximize user-friendliness.

  • The system supports various injection modes to match specific solid and liquid loading applications. When loading the sample into the loop, the device allows automatic injection after equilibration, allowing you to walk away as soon as the experiment starts. A clean loop option is available before or after a run without disconnecting any tubes.

Compare the Pure Excellence Chromatography System

  • Pure Excellence C-905

    C-905_comparison.tiff
    • Mode:Flash
    • Flow rate (flash mode):300 mL/min
    • Flow rate (prep HPLC mode):-
    • Pressure range (flash mode):0 - 50 bar
    • Pressure range (prep HPLC mode):-
    • UV scan function:No
    • UV-Vis wavelength range:UV fixed at 254, 275, 325, 365nm
    • ELSD:No
  • Pure Excellence C-910

    C-910_comparison.tiff
    • Mode:Flash
    • Flow rate (flash mode):300 mL/min
    • Flow rate (prep HPLC mode):-
    • Pressure range (flash mode):0 - 50 bar
    • Pressure range (prep HPLC mode):-
    • UV scan function:Yes
    • UV-Vis wavelength range:200 - 800 nm
    • ELSD:No
  • Pure Excellence C-915

    C-915_comparison.tiff
    • Mode:Flash
    • Flow rate (flash mode):300 mL/min
    • Flow rate (prep HPLC mode):-
    • Pressure range (flash mode):0 - 50 bar
    • Pressure range (prep HPLC mode):-
    • UV scan function:Yes
    • UV-Vis wavelength range:200 - 800 nm
    • ELSD:Yes
  • Pure Excellence C-950

    C-950_comparison.tiff
    • Mode:Flash & prep HPLC
    • Flow rate (flash mode):300 mL/min
    • Flow rate (prep HPLC mode):150 mL/min
    • Pressure range (flash mode):0 - 50 bar
    • Pressure range (prep HPLC mode):0 - 400 bar
    • UV scan function:Yes
    • UV-Vis wavelength range:200 - 800 nm
    • ELSD:Yes
“The ELSD capabilities were very important, and the integrated flash and prep HPLC system with fume enclosure allows us to operate the unit outside the fume hood, which was important since we didn’t have much free bench space.”Tze Chieh Shiao, Scientific Director Chemistry, - Glycovax Pharma Inc.

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Applications

From synthesis or extraction to pure compound isolation

For more than 40 years, BUCHI preparative chromatography equipment has been widely used for the purification of high value products. Compounds such as “Active Pharmaceutical Ingredients” (APIs) or specialty chemicals are generated by organic synthesis or extraction. The end result must always be further concentrated and purified. BUCHI purification solutions allow to purify compounds from a few milligrams up to several hundred grams. Together with a broad range of high performance consumables, we provide you the optimized solution suited to your purification workflow.
  • Academia

    Preparative chromatography education. Purification after synthesis or extraction.

    Academia
  • Chemicals

    Purification after synthesis. Preparative isolation of a compound from a formulation.

    Chemicals
  • Food

    Nutraceuticals: isolation of dietary supplements from natural compounds.

    Food
  • Pharmaceutical

    Purification of APIs after organic synthesis. Screening of natural compounds: isolation of various components after extraction. Biotechnology: purification after fermentation process.

    Pharmaceutical