Aplicações

Spray Drying of Mannitol

Mannitol is a sugar alcohol that is widely used in the food, pharmaceutical, and medical industries. It is commonly produced by the hydrogenation of glucose and is used as a bulking agent, sweetener, and flavor enhancer. Spray drying is a commonly used technique for producing dry powders from liquids, and has been applied to mannitol to create a dry, free-flowing powder with improved handling and storage characteristics.

The process of spray drying involves atomizing a solution of mannitol into a stream of hot gas, which evaporates the solvent and leaves behind a fine powder. The resulting mannitol powder has a controlled particle size distribution, high purity, and improved solubility.

Spray drying of mannitol has been used in a variety of applications, including the production of inhalable drugs, chewable tablets, and sugar-free confectionery products. The process can be used to modify the properties of mannitol, such as controlling its particle size and surface area, and improving its flow and compressibility.

In summary, spray drying of mannitol is a promising technology that offers a way to produce a dry, free-flowing powder with improved handling and storage characteristics. Its applications extend to many different areas of the food, pharmaceutical, and medical industries, including the production of inhalable drugs, chewable tablets, and sugar-free confectionery products.

Please see the application note No. 570 for starting parameters, formulations and some results.

Spray Drying of Methylene Blue

Methylene Blue (MB) is a synthetic dye with several potential medical applications. Spray drying is a useful technique for the production of MB powder, which can be used in various applications, including diagnostics and treatment.

Spray drying involves the atomization of a MB solution into a hot gas stream, which evaporates the solvent and leaves behind a fine powder of MB particles. The resulting MB powder has excellent stability and solubility, making it useful for several medical applications.

One of the primary applications of MB powder produced by spray drying is in diagnostics. It is used as a vital dye to stain cells and tissues for microscopic examination, and it is also used as a contrast agent in medical imaging procedures.

MB powder produced by spray drying also has potential applications in the treatment of several medical conditions, including methemoglobinemia, malaria, and Alzheimer's disease. The spray drying technique allows for the production of MB powder with high purity and consistent quality, which is critical for its various applications in medicine.

In summary, spray drying is a useful technique for the production of MB powder used in various medical applications, including diagnostics and treatment. MB powder produced by spray drying has excellent stability and solubility, making it useful for staining cells and tissues, medical imaging procedures, and treatment of medical conditions such as methemoglobinemia, malaria, and Alzheimer's disease.

Please see the application note No. 578 for starting parameters, formulations and some results.

Spray Drying of Lactoglobulin

Spray drying is a widely used process in the food industry to produce powders with improved stability, solubility, and functionality. Lactoglobulin is a whey protein commonly found in milk and is a rich source of essential amino acids.

The main areas of spray drying of lactoglobulin include the food and dietary supplement industries. In the food industry, spray-dried lactoglobulin is used as a functional ingredient in a variety of food products such as infant formula, sports nutrition products, and baked goods. Spray-dried lactoglobulin can improve the texture, flavor, and nutritional value of these products. In the dietary supplement industry, spray-dried lactoglobulin is used as a source of high-quality protein, which is essential for muscle growth and repair.

Overall, spray drying of lactoglobulin has a wide range of applications and is a crucial process for the manufacturing of high-quality food and dietary supplement products. The use of spray drying offers several advantages such as improved solubility, enhanced stability, and increased functionality, making it a preferred technique for the production of lactoglobulin powders in these industries.

Please see the application note No. 553 for starting parameters, formulations and some results.

Spray Drying of Gujazulen

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O guajazuleno é um pigmento azul-verde extraído das folhas da árvore Guazuma ulmifolia. Tem sido estudado pelo seu potencial uso nas indústrias cosmética e farmacêutica como agente antioxidante e anti-inflamatório. A secagem por pulverização é um método que tem sido investigado para produzir pó de guajazuleno para uso nessas aplicações.

As principais áreas de secagem por pulverização de guajazuleno incluem as indústrias cosmética e farmacêutica. Na indústria cosmética, o pó de guajazuleno é utilizado como ingrediente em vários produtos cosméticos, como cremes, loções e protetores solares, devido às suas propriedades antioxidantes e anti-inflamatórias. Na indústria farmacêutica, o pó de guajazuleno é usado no desenvolvimento de medicamentos anti-inflamatórios.

No geral, a secagem por pulverização de guajazuleno tem uma aplicação específica nas indústrias cosmética e farmacêutica. A utilização da secagem por pulverização pode oferecer várias vantagens, como uma maior estabilidade, biodisponibilidade e facilidade de manuseio, tornando-a uma técnica preferida para a produção de pó de guajazuleno nessas indústrias. No entanto, a otimização das condições de secagem por pulverização e a caracterização dos pós secos por pulverização são desafios significativos que precisam ser abordados para uma maior adoção do guajazuleno seco por pulverização na indústria.

Consulte a nota de aplicação para obter parâmetros iniciais, formulações e alguns resultados.

Spray Drying of Lonidamine

Lonidamine is an anticancer drug that has poor solubility and bioavailability, limiting its effectiveness in cancer treatment. Spray drying has been investigated as a method for improving the solubility and bioavailability of lonidamine by producing a dry, fine powder formulation.

The main areas of spray drying of lonidamine include the pharmaceutical and biotechnology industries. In the pharmaceutical industry, spray-dried lonidamine powders are used as a therapeutic agent for the treatment of various cancers. In the biotechnology industry, spray-dried lonidamine powders are used as a research tool for the study of cancer biology and drug delivery.

Overall, spray drying of lonidamine has a specific application in the pharmaceutical and biotechnology industries. The use of spray drying can offer several advantages such as improved solubility, bioavailability, stability, and ease of handling, making it a preferred technique for the production of lonidamine powders in these industries. However, the optimization of the spray drying conditions and the characterization of the spray-dried powders are significant challenges that need to be addressed for the wider adoption of spray-dried lonidamine in industry.

Please see the application note No. 565 for starting parameters, formulations and some results.

Mineral oil contamination in cardboard

Many food samples are often contaminated with mineral oil coming from different sources. One possible source of contamination is the migration from cardboard packaging made of recycled fibres. Mineral oils are complex mixtures of hydrocarbons. Due to the high number of isomers present, it is not possible to separate individual hydrocarbons by GC and, for this reason, GC traces are characterized by "humps" of unresolved peaks. Nevertheless, mineral oil contamination can be classified as mineral oil saturated hydrocarbons (MOSH), which are open chain paraffins, isoparaffins and cyclic naphthenes and mineral oil aromatic hydrocarbons (MOAH), comprising mainly alkylated 1-3 ring compounds.

Spray Drying of Mesalazine or Aminosalicylic Acid

Mesalazine (also known as 5-aminosalicylic acid) is a medication used to treat inflammatory bowel disease, such as ulcerative colitis and Crohn's disease. Spray drying has been used to produce mesalazine in powder form, allowing for improved storage, handling, and ease of use.

Spray drying of mesalazine involves atomizing a solution of the drug into a stream of hot gas, which evaporates the solvent and leaves behind a fine powder. The resulting powder has a controlled particle size distribution and improved solubility, making it easier to dissolve and absorb in the body.

The spray-dried mesalazine powder is used in the production of tablets, capsules, and suspensions for oral administration. The powder form allows for precise dosing and improved patient compliance, as it can be easily mixed with food or drink. The improved solubility also allows for more efficient absorption and distribution of the medication in the body.

In summary, spray drying of mesalazine allows for the production of a fine powder form of the medication, which improves its storage, handling, and ease of use. The spray-dried powder is used in the production of oral medications for the treatment of inflammatory bowel disease, improving dosing accuracy and patient compliance.

Please see the application note No. 574 for starting parameters, formulations and some results.

Lyophilisation of Traditional Chinese Medicine decoctions

Traditional Chinese Medicines (TCM) are usually prepared by mashing and boiling in water. This process is called decoction. Thereby, health beneficial compounds are extracted from herbal and plant material. If not directly administered, these extracts can be preserved for a longer shelf life using lyophilisation. In this Short Note we highlight the lyophilisation procedure of Tianma Gouteng Yin (TGY), as a TCM model decoction. TGY is a widely used medicine applied to treat Parkinson’s disease (PD) like symptoms. Recently, it has been reported that this TCM decoction exerts neuroprotective effects in animal and cell models of PD.

Lyophilisation of strawberries

Lyovapor™ L-200: Freeze Drying of strawberries

Here, we developed a freeze-drying method with optimized process time and residual moisture content for strawberries.

Spray Drying of Mustard

Spray drying is a process used to transform a liquid into a dry powder form. Mustard is a popular condiment and spice that is widely used in the food industry. Spray drying of mustard has been studied as a means of producing a fine powder with improved solubility, stability, and flavor.

The process of spray drying involves atomizing a solution of mustard into a stream of hot gas, which evaporates the solvent and leaves behind a fine powder. The resulting mustard powder has a controlled particle size distribution, good flowability, and high flavor retention.

Spray drying of mustard has been used in a variety of applications, including the production of flavoring agents, seasoning blends, and functional food ingredients. The process can be used to modify the properties of mustard, such as improving its solubility, reducing its pungency, and enhancing its flavor.

In summary, spray drying of mustard is a promising technology that has the potential to improve the performance and versatility of this widely used spice. Its applications extend to many different areas of the food industry, including the production of flavoring agents, seasoning blends, and functional food ingredients.

Please see the application note No. 585 for starting parameters, formulations and some results.

Spray Drying of Milk (skimmed)

Spray drying is a process used to transform a liquid into a dry powder form. Skimmed milk is a popular dairy product with a wide range of applications in the food industry. Spray drying of skimmed milk has been extensively studied as a means of producing milk powder with unique properties.

The process of spray drying involves atomizing a solution of skimmed milk into a stream of hot gas, which evaporates the water and leaves behind a fine powder. The resulting skimmed milk powder has a controlled particle size distribution, good reconstitution properties, and enhanced shelf life.

Spray drying of skimmed milk has been used in a variety of applications, including the production of infant formula, dairy products, and bakery products. The process can be used to modify the properties of skimmed milk, such as improving its solubility, increasing its nutritional value, and enhancing its flavor.

In summary, spray drying of skimmed milk is a promising technology that has the potential to improve the performance and versatility of this widely used dairy product. Its applications extend to many different areas of the food industry, including infant formula, dairy products, and bakery products.

Please see the application note No. 581 for starting parameters, formulations and some results.

Nano-precipited calcium carbonate (NPCC)

Sample concentration: 8.5 %Solvent: Water

Spray Drying of Morphine

Spray drying is a process used to transform a liquid into a dry powder form. Morphine is a potent analgesic drug used to manage severe pain. Spray drying of morphine has been studied as a means of improving the drug's solubility, bioavailability, and stability.

The process of spray drying involves atomizing a solution of morphine into a stream of hot gas, which evaporates the solvent and leaves behind a fine powder. The resulting morphine powder is highly dispersible and can be easily formulated into various dosage forms such as tablets or capsules.

Spray drying of morphine has been used in a variety of applications, including the production of sustained-release formulations, fast-dissolving tablets, and oral transmucosal systems. The process has also been used to improve the stability of morphine and to reduce the drug's gastrointestinal side effects.

In summary, spray drying of morphine is a promising technology that has the potential to improve the efficacy, safety, and convenience of this potent analgesic drug. Its applications extend to many different areas of drug delivery, including sustained-release formulations and fast-dissolving dosage forms.

Please see the application note No. 583 for starting parameters, formulations and some results.

Óleo e graxa em água residual (UniversalExtractor E-800)

Esta nota de aplicação descreve a extração e a determinação de óleo e graxa de amostras de água residual seguindo os métodos padrão AWWA 5520 parte D (método de extração Soxhlet). “Óleo e graxa” são definidos como qualquer material recuperado como substância solúvel no solvente. A amostra de água residual é acidificada com ácido clorídrico e extraída usando o método de extração Soxhlet no UniversalExtractor E-800. Após o extrato ter sido seco até atingir um peso constante, a amostra de óleo e graxa é determinada por gravimetria. Esta nota de aplicação é adequada para lipídios biológicos, hidrocarbonetos minerais e também para a maioria das águas residuais industriais. Não é aplicável a frações de baixo ponto de ebulição que vaporizam abaixo de 85°C.

Spray Drying of Oil in Gelatin Microparticles

Spray drying is a common technique used to produce oil-encapsulated particles. Oil in gelatin microparticles can be produced using this technique. The process involves the formation of an emulsion containing oil, a gelatin solution, and a surfactant. The emulsion is then spray-dried, resulting in small, dry particles that can be used in a variety of applications. The use of gelatin as a matrix for encapsulation allows for the release of the oil in a controlled manner, making it a desirable ingredient in food and cosmetic products.

Oil in gelatin microparticles have numerous applications in the food, cosmetic, and pharmaceutical industries. They can be used as a source of nutrients or flavor in food products, as well as in the formulation of cosmetic products such as lotions and creams. Additionally, they can be used in the pharmaceutical industry as drug delivery systems, allowing for the controlled release of drugs in the body. The spray-drying process can be customized to achieve specific particle sizes and oil loadings, allowing for the production of particles with tailored properties to meet the needs of different applications.

Please see the application note No. 590 for starting parameters and some results.

Spray Drying of Nylon 6 (polyamide)

Spray drying is a process used to transform a liquid into a dry powder form. Nylon 6 (polyamide) is a widely used polymer with applications in many different industries, including textiles, automotive, and packaging. Spray drying of nylon 6 has been studied as a means of producing fine powders with unique properties.

The process of spray drying involves atomizing a solution of nylon 6 into a stream of hot gas, which evaporates the solvent and leaves behind a fine powder. The resulting nylon 6 powder has a controlled particle size distribution, high surface area, and unique morphology.

Spray drying of nylon 6 has been used in a variety of applications, including the production of high-performance fibers, films, and coatings. The process can be used to modify the properties of nylon 6, such as increasing its thermal stability, improving its processability, and enhancing its mechanical properties.

In summary, spray drying of nylon 6 is a promising technology that has the potential to improve the performance and versatility of this widely used polymer. Its applications extend to many different areas of industry, including textiles, automotive, and packaging.

Please see the application note No. 589 for starting parameters, formulations and some results.

Spray Drying of Orange flavour

Spray drying is a common technique used in the food industry to produce powders from liquid concentrates. Orange flavour is one such concentrate that can be spray dried to produce a powdered form. The process involves atomizing the liquid concentrate into small droplets which are then exposed to hot air, resulting in the evaporation of the water content and formation of a dry powder. Spray drying of orange flavour offers several benefits such as improved shelf life, enhanced stability, and ease of handling and storage.

Spray dried orange flavour powder finds wide application in the food industry as a flavoring agent in various products such as baked goods, confectioneries, beverages, and dairy products. It can also be used in the pharmaceutical industry to impart orange flavor to medicinal products. The powder form provides better uniformity of flavor, easy dosing, and faster solubility in water-based products. Spray dried orange flavour is also popularly used in the cosmetic industry for the formulation of perfumes, body sprays, and other personal care products.

Please see the application note No. 593 for starting parameters and some results.

Spray Drying of Oxytocyn acetate

Spray drying of oxytocin acetate is a process of converting liquid oxytocin acetate into dry powder form using a spray dryer. Oxytocin acetate is a synthetic hormone used to induce labor, prevent or control bleeding after childbirth, and in the treatment of breast pain or discomfort. Spray drying is a commonly used technique to produce stable and easily transportable formulations of oxytocin acetate that can be used in various pharmaceutical products.

The spray drying process of oxytocin acetate involves atomizing the liquid into a fine mist and then exposing it to hot air. The liquid droplets quickly evaporate, leaving behind dry powder particles. The resulting powder has a longer shelf life, better stability, and improved solubility in water.

The use of spray drying for oxytocin acetate has been crucial in the development of safe and effective pharmaceutical products for maternal health. This process has allowed for the easy storage and transportation of oxytocin acetate, making it more accessible to people in remote areas where refrigeration may not be readily available. It has also helped in the development of new formulations of oxytocin acetate that can be administered through different routes of administration, such as oral or nasal sprays, for improved patient convenience and compliance.

Please see the application note No. 597 for starting parameters, formulations and some results.

Spray Drying of Olive leaf extract

Spray drying of olive leaf extract involves the conversion of liquid extracts into dry powder form by evaporating the solvent under controlled temperature and pressure. Olive leaf extract is rich in phenolic compounds such as oleuropein, hydroxytyrosol, and tyrosol, which are known for their potent antioxidant and anti-inflammatory properties. The spray-drying technique helps to preserve these bioactive compounds and extend the shelf life of the extract.

Olive leaf extract is used in various industries, including food, nutraceutical, and pharmaceuticals. It is commonly used as a dietary supplement due to its beneficial effects on cardiovascular health, immune system function, and blood sugar regulation. It is also added to various food products, such as dressings, marinades, and sauces, to enhance their nutritional value and antioxidant activity. In the pharmaceutical industry, olive leaf extract is used as an active ingredient in topical and oral formulations for the treatment of various skin conditions and infections.

Overall, spray drying of olive leaf extract has numerous applications and provides a convenient and effective way to obtain a stable and bioactive powder for various industries.

Please see the application note No. 591 for starting parameters and some results.

Spray Drying of P 6 (Sexual attractant)

Spray drying has been used to create a more stable formulation of Pheromone P6, a sexual attractant compound used for pest management in agriculture. Spray drying has the advantage of producing dry and free-flowing powders, which are easy to handle and store. This technique can also be used to modify the release properties of the compound, leading to better pest management strategies. The spray-dried P6 formulation can be incorporated into dispensers, which release the pheromone over a specific period, mimicking the natural release of the compound by the insects. The use of spray-dried P6 formulations has shown promising results in controlling the population of certain pests, such as fruit flies and moths, which can cause significant damage to crops. Overall, spray drying is a valuable tool in the formulation and delivery of pheromones, aiding in the development of effective and sustainable pest management strategies in agriculture.

Please see the application note No. 598 for starting parameters, formulations and some results.