Sepiatec SFC Systems

The green standard for fast compound isolation

Sepiatec SFC systems were designed for preparative separations by SFC chromatography and are extremely easy to use. They take less space than expected to satisfy any requirements, from basic to complex tasks,  on a small or large scale.

  • Detection:UV; ELSD and MS (optional)
  • Pump:Prep SFC mode
  • System Design:Compact and fully automated
Sepiatec SFC Systems

Easy to handle

With Sepiatec SFC systems, BUCHI makes preparative separations by SFC chromatography usable for everyone. The instruments have been specifically designed with a focus on ease of use, thanks to several key features.

Easy to handle

Space saving

Space is a precious commodity in every lab. Sepiatec SFC systems are the most compact on the market, allowing for the optimal use of valuable space without compromising quality and efficiency.  

Space saving

Highest flexibility

The needs of the chemist vary depending on the application. The comprehensive Sepiatec SFC instrument portfolio supports flexibility in a number of ways.   

Highest flexibility

Features

  • The entire Sepiatec SFC device runs dedicated software developed by SFC experts. A clear menu structure enables a simple and intuitive process with dedicated functions such as stack injection, peak detection, and on-the-fly editing for changing parameters during a run. All input options are presented on just a few screens. Data is entered via the 15.6‘‘ touchscreen, which has been placed ergonomically on the upper front of all Sepiatec SFC systems.
    Profit from the expert
  • Stack injection mode is used when working with large sample amounts and requires an isocratic gradient mode. This technique allows for the successive injection of additional samples and utilizes the time spent waiting for peak elution. The Sepiatec Prep SFC Control software automatically suggests stacking time and therefore makes the setup of a stacked injection method extraordinarily simple.
    Large scale injection in no time
  • A simple setup makes becoming familiar with the instrument a breeze; therefore, time-intensive training sessions are unnecessary. Everything has been thought of, including a connection piece for an exhaust system by default. In addition, all Sepiatec SFC systems can be operated on a benchtop or a fume hood.
    A simple but smart instrument setup
  • All Sepiatec SFC instruments, from small to large-scale purification, require a minimum footprint in the laboratory. The system controller and fraction collector are built into the device and need no extra space beside the instrument. Therefore, precious lab space, be it in or out of a fume hood, can be saved and used for other equipment.
    Minimal lab space
  • Even being the smallest on the market, Sepiatec SFC systems come with everything required to run supercritical fluid chromatography without compromise.
    All in one
  • Sepiatec SFC instrument design stands out due to its modular design, which is highly service-friendly by allowing access to all parts from the front. Replacement of spare or worn parts is quick and easy as there is no need to move or turn the instrument.
    Service made easy
  • Sepiatec SFC systems cover the full range of separation needs, handling sample capabilities in the mg to gram range. Pumps with different flow rate ranges allow for prep HPLC columns of various sizes, accommodating internal diameters ranging from 4-16mm, 15-30mm, and 30-50mm and lengths from 150-800mm. Depending on the model, up to 10 columns can be stored in the column oven simultaneously and connected for screening if required.
    Various models for different performance levels
  • Monitoring the separation of a mixture's compounds is crucial for successful purification as it ensures the proper collection of the target compound. All Sepiatec SFC systems are equipped with a UV detector but also allow the connection of an Evaporative Light Scattering Detector (ELSD) and Mass Spectrometer (MS). Sample injection can be done on the Sepiatec SFC instrument in two ways: multiple and stacked. Stacked injections are useful when injecting large sample amounts under isocratic solvent conditions, while multiple injections are done sequentially.
    Versatile options for detection and injection
  • With Sepiatec SFC systems, fractions are collected in an unpressurized state. Thereby, not only is safety increased but also handling is simplified. There is no limitation concerning the size of fraction volumes. This option proves to be highly convenient when working with stacked injections.
    Fraction collection at any size

Compare the Sepiatec SFC Systems

  • Sepiatec SFC-50

    • Mode:prep SFC
    • Max operating pressure:400 Bar
    • Total flow rate at 40% modifier:50 ml/min
    • Column dimensions:4-16 mm ID, max 250 mm lengths
    • DAD wavelengths range:190-720 nm
    • ELS & MS Detector:optional
    • CO2 recycling:No
    • Column selection valve:optional
    • Multi sample and fraction module:optional
    • Add-on pump:optional
  • Sepiatec SFC-250

    • Mode:prep SFC
    • Max operating pressure:400 Bar
    • Total flow rate at 40% modifier:250 ml/min
    • Column dimensions:15-30 mm ID, max 250 mm lengths
    • DAD wavelengths range:190-720 nm
    • ELS & MS Detector:optional
    • CO2 recycling:optional
    • Column selection valve:optional
    • Multi sample and fraction module:optional
    • Add-on pump:standard integrated
  • Sepiatec SFC-660

    • Mode:prep SFC
    • Max operating pressure:400 Bar
    • Total flow rate at 40% modifier:660 ml/min
    • Column dimensions:30-50 mm ID, max 800 mm lengths
    • DAD wavelengths range:190-720 nm
    • ELS & MS Detector:optional
    • CO2 recycling:optional
    • Column selection valve:No
    • Multi sample and fraction module:No
    • Add-on pump:standard integrated

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Applications

SFC unlimited for any application

Sepiatec SFC system portfolio is designed to make any application possible, including drugs, natural products, fine & specialty chemicals, or cosmetics & fragrances generated by organic synthesis or extraction. The instruments stand out due to several convincing features that will encourage beginners and satisfy advanced users. Combining usability and flexibility in the market’s smallest SFC system makes preparative separations by SFC chromatography accessible to everyone.
  • Academia

    Preparative chromatography education. Purification after synthesis or extraction.

    Academia
  • Chemicals

    Purification after synthesis. Preparative isolation of a compound from a formulation.

    Chemicals
  • Pharmaceutical

    Purification of APIs after organic synthesis. Screening of natural compounds: isolation of various components after extraction. Biotechnology: purification after fermentation process.

    Pharmaceutical
  • Food

    Nutraceuticals: isolation of dietary supplements from natural compounds.

    Food