Freeze-dryers were initially intended to be used with water as a solvent. With new applications, freeze-drying is consequently being used more and more in combination with organic solvents instead of water. Organic solvents and inorganic acids and bases are often used in research and development prior to lyophilisation of the sample. The behavior of these new types of samples during freeze-drying must therefore be considered prior to the process.
Lyophilisation of truffles
Truffles are products with limited shelf life and their sensory properties are rapidly lost. Hence, the expensive fungi become less valuable within a few days. Losses of volatile compounds, oxidation and enzymatic reactions are a considerable problem during their storage. Furthermore, the aroma profile is commonly modified as a result of elevated temperature processes or enzymatic reactions. Freeze drying the fungi avoids loss and degradation of volatile compounds due to the low temperatures applied during drying. The aromatic profile of truffles are maintained. Freeze dried truffles can either be rehydrated or directly used in dry form.
Lyophilisation of mannitol and NaCl solutions in serum vials
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
Lyophilisation of fresh banana slices
Freeze drying is a gentle form of drying and may be used to preserve foods without changing their appearance or taste. The freeze drying process includes the freezing of the food sample and subsequent applying a fine vacuum to the frozen sample. Under these conditions, the water in the food will sublimate, hence, the sample dries. In food applications, freeze drying is commonly used to make instant coffee and to dry and conserve fruits, vegetables or herbs.
Freeze drying of beads containing yeasts
The cell viabilities of microorganisms during storage are of economic importance for probiotic dietary food and feed supplements. By combining granulation and freeze drying, dust free particles homogeneous in size and composition can be obtained. This will enable a good particle flowability, an easier dosage and a faster reconstitution of the product can be obtained. Encapsulator as a granulator to prill the yeasts suspension into liquid nitrogen and form monodispersed beads that will then be freeze dried.
该指导手册全面概述了 NIR 和参考方法（例如，脂肪萃取和凯氏定氮法用于蛋白质测定）如何在食品加工链的所有步骤中使用。详细了解这些技术，包括样品制备、监管措施、故障排除、常见问题解答和案例特定研究。
冷冻干燥指导第 2 期：面向普通用户的插图工具包
Cosmetics Lab 杂志第 1 期
Cosmetics Lab 杂志第 2 期
在《COSMETICS LAB》第 2 期中，获得有关如何将天然原料转变为活性化合物的有用信息。从化妆品开发所有步骤使用的技术方面的有用信息中受益。了解如何萃取和筛选活性成分，以及如何使用色谱法纯化原材料。还提供有趣的实例、星座运势、测验和有关打击化妆品行业误导信息的专访。
Cosmetics Lab 杂志第 3 期
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Cosmetics Lab 杂志第 4 期
在《COSMETICS LAB》第 4 期中，获得有关化妆品行业中用于质量控制的现代和成熟技术的知识。了解如何通过优化质量控制流程来有力地证明产品安全性和性能。具体主题包括：使用加压液体萃取 (PLE) 制备绿色样品、用于质量控制的色谱检测器的优点和局限性、进行痕量金属元素分析的重要性、NIR 如何加快质量控制流程等。
完整色谱百科为您提供开发和执行最佳快速色谱和 HPLC 制备方法的基本知识。依靠简洁的理论和对色谱过程所有部分的清晰解释。使用色谱基础知识，通过耗材、检测方法、最适合您的应用的固定相和流动相来开发自己的方法。
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Nitrogen Determination in Nitrate Containing Fertilizers
Nitrogen Determination in Nitrate Containing Fertilizers according to AOAC 955.04-D (Kjeldahl Method) – Block Digestion
Pre-Extraction and Extraction of Hypericin in St. John's Wort (Hypericum perforatum) using the SpeedExtractor E-916
SpeedExtractor E-916: Pre-Extraction and Extraction of Hypericin in St. John's Wort (Hypericum perforatum) using the SpeedExtractor E-916
PLGA sub-micron particles by Nano Spray Drying
Nano-spray drying for drug delivery of smallest particles
Nitrogen and protein determination in tofu
Nitrogen and protein determination in tofu according to the Kjeldal method (back titration)