Applications

Spray Drying of Peptide H-5 CDD 19

Spray drying of peptide H-5 CDD 19 is a technique used to convert a liquid peptide solution into a dry powder form. The process involves atomizing the solution into small droplets and passing them through a stream of hot air, which evaporates the solvent leaving behind a powder form of the peptide. This method is often used in pharmaceutical industries for the development of peptide-based drug formulations.

Peptide H-5 CDD 19 is a modified version of the peptide hormone called gastrin-releasing peptide (GRP) that has been shown to be effective against certain types of cancer. Spray drying of this peptide can increase its stability and shelf life, making it easier to store and transport. This technique can also enhance the bioavailability of the peptide, allowing it to be absorbed more easily by the body.

In addition to pharmaceutical applications, spray drying of peptides has also been used in the food and cosmetic industries for the development of functional ingredients and delivery systems. Peptides can be incorporated into food and cosmetic formulations to provide various health and aesthetic benefits such as improved skin texture and increased muscle mass. Spray drying of these peptides can enhance their stability and effectiveness, making them more suitable for use in these applications.

Please see the application note No. 604 for starting parameters and some results.

Spray Drying of Polyvinylacetate

Polyvinyl acetate (PVAc) is a synthetic polymer with a broad range of applications in various industries such as adhesives, coatings, and textiles. Spray drying is a technique that has been applied to the production of PVAc powders, offering several advantages in terms of product quality, performance, and process efficiency.

Spray drying of PVAc allows for the production of powders with controlled particle size and morphology, which can be tailored to specific applications. The resulting powders have high purity, low dust content, and improved solubility, making them suitable for a wide range of processing and manufacturing applications.

Applications of PVAc powders produced by spray drying include the manufacture of adhesives, coatings, and other high-performance materials. The process can also be used to produce PVAc powders with enhanced properties, such as increased stability, water resistance, and adhesive strength.

Overall, spray drying of PVAc offers numerous benefits and has a wide range of potential applications in various industries, including construction, manufacturing, and materials science. Its versatility and adaptability make it a valuable tool for the development of new and innovative products.

Please see the application note for starting parameters and some results.

Nitrogen and protein determination in dairy products

Nitrogen Determination in Pharmaceuticals

Nitrogen determination is one of the key analyses performed in quality control. The samples require digestion with sulfuric acid to convert nitrogen into ammonium sulfate. After conversion to ammonia through the alkalinization with sodium hydroxide, the sample is distilled into a boric acid receiver by steam distillation, followed by a titration with hydrochloric acid solution.

Nitrogen and Protein Determination in Dairy Products (Kjeldahl Tablets)

Protein determination is one of the key analyses performed in the food industry. The samples require digestion with sulfuric acid to convert nitrogen into ammonium sulfate. Hydrogen peroxide is used to accelerate the digestion process. After conversion to ammonia through the alkalinization with sodium hydroxide, the sample is distilled into a boric acid receiver by steam distillation, followed by a titration with sulfuric acid solution. The nitrogen content is multiplied by a sample-specific protein factor (6.38 for dairy products) to obtain the protein content.

Nitrogen and Protein Determination in Bran Products

Protein determination is one of the key analyses performed in the food industry. The samples require digestion with sulfuric acid to convert nitrogen into ammonium sulfate. After conversion to ammonia through the alkalinization with sodium hydroxide, the sample is distilled into a boric acid receiver by steam distillation, followed by a titration with sulfuric acid solution. The nitrogen content is multiplied by a sample-specific factor (5.7 for wheat and oat) to obtain the protein content.

Nitrogen determination in nitrate free fertilizer according to the micro-Kjeldahl method

Nitrogen and protein determination in pasta

Protein determination is one of the key analyses performed in the food industry. The samples require digestion with sulfuric acid to convert nitrogen into ammonium sulfate. After conversion to ammonia through the alkalinization with sodium hydroxide, the sample is distilled into a sulfuric acid receiver by steam distillation, followed by a back titration with sodium hydroxide solution. The nitrogen content is multiplied by a sample-specific factor (6.25 for pasta) to obtain the protein content.

Nitrogen and protein determination in dairy products

Process intensification by Sepacore Easy systems

Liquid chromatography can be carried out in many ways. Even tough high-efficiency liquid chromatography techniques exist (e.g. HPLC, UPLC), common procedures of gravity column- and flash chromatography are still important and cannot be considered to be replaced, especially on the preparative scale. Small, semi-automated flush purification systems (e.g. Easy Synthesis) greatly increase the productivity compared gravity column chromatography.

Spray Drying of Polyvinylpyrrolidone

Polyvinylpyrrolidone (PVP) is a synthetic polymer with a broad range of applications in various industries such as pharmaceuticals, cosmetics, and food. Spray drying is a technique that has been applied to the production of PVP powders, offering several advantages in terms of product quality, performance, and process efficiency.

Spray drying of PVP allows for the production of powders with controlled particle size and morphology, which can be tailored to specific applications. The resulting powders have high purity, low dust content, and improved solubility, making them suitable for a wide range of processing and manufacturing applications.

Applications of PVP powders produced by spray drying include the manufacture of drug delivery systems, cosmetics, and other high-performance materials. The process can also be used to produce PVP powders with enhanced properties, such as increased solubility, stability, and bioavailability.

Overall, spray drying of PVP offers numerous benefits and has a wide range of potential applications in various industries, including healthcare, cosmetics, and food production. Its versatility and adaptability make it a valuable tool for the development of new and innovative products.

Please see the application note No. 624 for starting parameters and some results.

Spray Drying of Polysulfone

Polysulfone (PSU) is a high-performance thermoplastic material with a broad range of applications in various industries such as aerospace, automotive, and electronics. Spray drying is a technique that has been applied to the production of PSU powders, offering several advantages in terms of product quality, performance, and process efficiency.

Spray drying of PSU allows for the production of powders with controlled particle size and morphology, which can be tailored to specific applications. The resulting powders have high purity, low dust content, and improved solubility, making them suitable for a wide range of processing and manufacturing applications.

Applications of PSU powders produced by spray drying include the manufacture of coatings, films, and other high-performance materials. The process can also be used to produce PSU powders with enhanced mechanical properties, such as increased toughness, stiffness, and thermal resistance.

Overall, spray drying of PSU offers numerous benefits and has a wide range of potential applications in various industries, including engineering, manufacturing, and materials science. Its versatility and adaptability make it a valuable tool for the development of new and innovative products.

Please see the application note No. 622 for starting parameters and some results.

Production of uniform poly-lactic acid beads

Poly-lactic acid (PLA) microbeads with spherical shape having a diameter around 550 μm were produced using a three-step process. Firstly, uniform PLA droplets (dissolved in DCM) were stabilized in a calcium-alginate shell. Then the organic solvent was evaporated and finally, the PLA microspheres were recovered by dissolution of the alginate shell in tri-sodium citrate solution. Active pharmaceutical ingredients (APIs) could be embedded in the PLA matrix to extend the shelf live, increase the bioavailability as well as retarding its release.

Spray Drying of Pollen

Spray drying of pollen involves transforming pollen grains into a dry powder form by atomizing them into a hot gas stream. The process helps to increase the shelf life of pollen and improve its preservation. The resulting powder is also easy to transport and use in various applications.

Spray drying of pollen is commonly used in the food industry to incorporate pollen into various food products such as bread, cheese, and yogurt. Pollen is rich in nutrients, including protein, amino acids, vitamins, and minerals, and can be used as a natural supplement in functional foods. In addition, pollen has been used in traditional medicine to treat allergies, respiratory ailments, and digestive problems.

The process of spray drying also ensures that the beneficial properties of the pollen are preserved during the drying process, and it can be used in other applications, such as in cosmetics, where it can be added to skincare products for its antioxidant properties. The powder form of pollen is also easier to handle and store, making it ideal for long-term preservation and commercial use.

Please see the application note No. 613 for starting parameters and some results.

Spray Drying of Polyethersulfone

Polyethersulfone (PES) is a high-performance polymer that is widely used in the manufacture of membranes, filters, and other porous materials. Spray drying is a technique that has been applied to the production of PES powders, offering several advantages in terms of product quality, performance, and process efficiency.

Spray drying of PES allows for the production of powders with controlled particle size and morphology, which can be tailored to specific applications. The resulting powders have high purity, low dust content, and improved solubility, making them suitable for a wide range of processing and manufacturing applications.

Applications of PES powders produced by spray drying include the manufacture of membranes for filtration, separation, and purification processes, as well as the production of composite materials, adhesives, and coatings. Spray drying of PES has also been explored as a technique for the encapsulation of bioactive compounds, such as drugs and probiotics, due to its ability to produce particles with high encapsulation efficiency and controlled release properties.

Overall, spray drying of PES offers numerous benefits and has a wide range of potential applications in various industries, including biotechnology, pharmaceuticals, and materials science. Its versatility and adaptability make it a valuable tool for the development of new and innovative products.

Please find starting parameters and some Results in this Application Note No. 620.

Production of pectin-oligochitosan beads

The Encapsulator B-390 / B-395 Pro is widely applied in a single-step process for the encapsulation of drugs, flavor & fragrances, pigments, nutrition supplements as well as microorganisms. Alginate is often the matrix material of choice due to its availability and good bead forming properties.This Short Note describes the use of pectin as matrix material. Pectin is a biodegradable and biocompactible polymer from natural source.Chelation with oligochitosan enables to use pectin with the Encapsulator for bead manufacturing.Here, the protocol and required steps for pectinoligochitosan microbead formation is presented. Such alginate-free microbeads show excellent capability for drug delivery applications.

Polycyclic aromatic hydrocarbons in sludge samples

Polycyclic aromatic hydrocarbons (PAHs) are organic compounds of hydrogen and carbon, composed of numerous aromatic rings. There are more than 150 such compounds containing two or more benzene rings, such as naphthalene (NAP) and anthracene (ANT). PAHs are nonpolar and lipophilic and primarily found in natural sources such as creosote. They are also produced through the incomplete combustion of organic matter. Nowadays, the main sources of PAH pollution, are caused by human activity and vary across the globe. Most PAHs enter the environment via the atmosphere through processes of combustion and pyrolysis. PAHs have been detected in a variety of foods due to the deposition of airborne PAHs, as well as in fish from contaminated waters. PAHs are also formed during certain methods of food preparation such as charbroiling, grilling, roasting and frying. The respiratory tract and the skin are the two organs most affected by PAHs in the human body. Common symptoms include solar dermatitis, acne dermatitis and epifolliculitis. Many countries and regions have regulations to prohibit and detect the compounds of PAHs.In 1982, the American Environmental Protection Agency (EPA) introduced 16 representative PAHs as priority compounds for the monitoring of pollutants5. In 2016, the Ministry of Ecology and Environment of the People’s Republic of China published a new series of decrees and regulations regarding PAHs in environmental areas such as soil, sediment, sludge and air. The regulations clearly list the detection methods and value limits for PAH compounds in different applications. In the regulations HJ 783-2016 and HJ 805-2016, they recommend the extraction of a solid sample using the Pressurized Fluid Extraction method (PFE, also known as Pressurized Solvent Extraction PSE) of lyophilized samples prior to analysis by GC-MS.

Spray Drying of Polyacrylate and Silica Nanosuspensions

Spray drying is a popular method for producing polyacrylate and silica nanosuspensions in large quantities. The process involves mixing the polymers with water and silica, and then spray drying the mixture into fine particles. The resulting nanosuspensions have a high surface area and can be easily dispersed in various liquids.

Polyacrylate and silica nanosuspensions have various applications in different fields. In the cosmetics industry, they are used as skin care products, hair care products, and sunscreens due to their ability to provide UV protection and improve the texture of the skin and hair. In the pharmaceutical industry, they are used in drug delivery systems to enhance the bioavailability of drugs and improve their stability.

Polyacrylate and silica nanosuspensions are also used in the food industry as food additives to improve the texture and stability of various products, such as dairy products, beverages, and sauces. In addition, they have potential applications in the field of energy, as they can be used in the fabrication of photovoltaic devices and energy storage systems. Overall, the spray drying of polyacrylate and silica nanosuspensions has wide-ranging applications in various industries due to their unique properties and versatility.

Please see the application note No. 616 for starting parameters and some results.

Homogenizing of Samples with High Water, Fat and Fibre Content

In analytical chemistry accuracy of results are decisively depending on sample preparation. Due to this the requirements of laboratory mixing devices are very high. The BÜCHI Mixer B400 is impressively showing its efficiency for samples with high water, fat and fibre content.

Spray Drying of Indigo water soluble

Indigo is a natural dye that has been used for centuries to color textiles. In recent years, there has been an increasing interest in using indigo in a variety of applications, including cosmetics, food, and pharmaceuticals. However, one of the challenges in using indigo is its limited solubility in water, which can hinder its use in certain applications.

Spray drying is a potential solution to this problem. By converting indigo into a water-soluble form and then spray drying it, the resulting powder can be easily incorporated into a wide range of products. The spray-dried indigo powder can be used as a natural blue food colorant, a cosmetic ingredient, or a pharmaceutical excipient.

Spray drying of indigo requires careful optimization of several parameters, such as the type of carrier material, the drying temperature, and the concentration of the indigo solution. The resulting powder should have good solubility in water, a consistent color, and stability over time.

Overall, spray drying of indigo offers a promising approach to expand the use of this natural dye in various applications, providing a water-soluble form with improved functionality and versatility.

Please see the application note No. 542 for starting parameters, formulations and some results.