“Active Pharmaceutical Ingredients” (APIs) are generated by organic synthesis, biochemical process or extraction. The end result must always be further concentrated and purified. BUCHI chromatography solutions allow the purification of compounds from a few milligrams up to several hundred grams. Our solutions cover the complete sample range and allow simple up-scale from lab to production scale.
|Prep HPLC Chromatography||Flash & Prep HPLC Chromatography|
|Maximum pressure (bar/psi)||50 / 725||300 / 4350||flash: 50/725
prep HPLC: 300 / 4350
|Maximum flow rate (mL/min)||250||100||flash: 250
|UV-Vis detection||200 – 400 nm
optional Vis (400-800nm)
|200 – 800 nm||200 – 800 nm|
|ELS detector||no / Integrated||no / Integrated||Integrated|
The samples complexity, purity or polarity as well as the amount to purify dictate the choice of the column. The type of columns selected must not only allow to perform the separation, but also be compatible with the economical requirements. BUCHI has a column for almost any flash chromatography application: prepacked or empty cartridges, glass columns allow the purification of compounds from a few milligrams up to several hundred grams.
|Flash cartridges||Glass columns||Prep columns|
|Size||4 to 3200 g||ID (mm): 15, 26, 36, 49, 70, 100||ID (mm): 4.6 to 70|
|Length (mm): 100, 230, 460, 920||Length (mm): 150, 250|
|Packing material||Si, C18, C18WP, Amino, Diol, Alumina||up to customer||Si, C18, C18AQ, C4|
|Particle size||15, 20, 30, 40, 50, 60 µm||up to customer||5, 10, 15 µm|