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Purification (Chemical)

“Active Pharmaceutical Ingredients” (APIs) are generated by organic synthesis, biochemical process or extraction. The end result must always be further concentrated and purified. BUCHI chromatography solutions allow the purification of compounds from a few milligrams up to several hundred grams. Our solutions cover the complete sample range and allow simple up-scale from lab to production scale.

  Flash chromato-
graphy
Prep HPLC Chromatography Flash & Prep HPLC Chromatography
 
Maximum pressure (bar/psi) 50 / 725 300 / 4350 flash: 50/725
prep HPLC: 300/4350
Maximum flow rate (mL/min) 250 100 flash: 250
prep HPLC:100
UV-Vis detection 200-400 nm
optional Vis (400-800 nm)
200 – 800 nm 200 – 800 nm
ELS detector no / Integrated no / Integrated Integrated
Application overview Applications

 

The samples complexity, purity or polarity as well as the amount to purify dictate the choice of the column. The type of columns selected must not only allow to perform the separation, but also be compatible with the economical requirements. BUCHI has a column for almost any flash chromatography application: prepacked or empty cartridges, glass columns allow the purification of compounds from a few milligrams up to several hundred grams.

  Flash cartridges Glass columns Prep columns
 
Size 4 to 3200 g ID (mm): 15, 26, 36, 49, 70, 100 ID (mm): 4.6 to 70
Length (mm): 100, 230, 460, 920 Length (mm): 150, 250
Packing material Si, C18, C18WP, Amino, Diol, Alumina up to customer Si, C18, C18AQ, C4
Particle size 15, 20, 30, 40, 50, 60 µm up to customer 5, 10, 15 µm