Spray Drying of Amifostine
Amifostine is a cytoprotective agent used to reduce side effects of cancer therapies. Spray drying enables the production of stable, patient-friendly powders with optimized particle properties and bioavailability. It supports oral formulations with controlled release for improved therapeutic outcomes. Application Note No. 427 provides starting parameters, formulations, and results, including Amifostine/PLGA concentrations and solvent systems.
Amifostine/PLGA의 샘플 농도 (0.4:1.0 및 1:1), Amifostine (400mg/1ml 또는 1000 mg/2ml)를 이온 제거된 물에 용해하고, 1 g의 PLGA가 포함된 50mL의 디클로로메탄에 유화시킵니다. 수용액 중의 Amifostine 용매, DCM 운반체 내의 PLGA, 필모젠 Poly (DL-락틱–글리콜산) PLGA 50:50 (RG 502; 고유 점도 0.2 dL/g), 인지질콜린 (계면활성제).
