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Modifying particle size in a lab spray dryer – from “trial and error” to DoE

Modifying particle size in a laboratory spray-dryer setup can be quite challenging, especially if particles with larger diameter are requested. Altering process and formulation parameters with the most significant impact on particle size is not obvious but can negatively affect product characteristics such as residual moisture or yield.

In the first part of the webinar, after the introduction to pharmaceutical and laboratory spray drying, the systematic tool “Design-of-Experiments” (DoE) is introduced. DoE enables the control of product particle size while focusing on product quality. This will be shown exemplary for the manufacture of biodegradable polymer particles from organic solutions.

Based on the knowledge from the DoE experiments, the second part focuses on an in situ microencapsulation method. Encapsulation is done with a dual-liquid feed coaxial nozzle, whereby the emulsion for solvent evaporation is created at the tip of the nozzle. This allows minimizing of contact time and drug-excipient incompatibility problems.

• Learn about the application of DoE in spray-drying
• Hear about morphology engineering aspects
• Learn how better to control your lab spray-drying process
• Learn how to manufacture biodegradable microcapsules with sensitive actives