Solution «Spray Drying Small» (200 nm – 5 μm)

Laboratory Spray Drying for small samples and particles

You deal with expensive sample materials or want to obtain the smallest particles. We provide a solution with three patented technologies to support you in your research work and offer you new possibilities.

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Overview

Benefits

Efficient

Protect your high valuable sample material while working with extremely small sample volumes (>150 mg or >2 ml)
High yields obtained with the sample material protective design (< 90%)
Straightforward application with help of online application database

Flexibility

Ability to work with even very expensive sample materials
Use for spray drying and microencapsulation
Three mashes of the unique spray head enables production of smallest particles (200 nm – 5 μm)
Spray drying of organic solvent based or aqueous samples

Convenient

Easy manipulation of the different parameters
Recovery of process data with Nano Spray Dryer Record software
Process control due to glass assembly

Voice of the customer

The BUCHI spray drying devices were indispensable tools for laboratory scale studies of APIs and organic excipients behaviours.

Mr. Damiens Martins, Université de Rouen

Université de Rouen, Laboratoire SMS EA3233, France

Scope

Nano Spray Dryer B-90 Application Support

Applied products

Dehumidifier B-296

Inert Loop B-295

Service & Support

Free online application database
Customized application support
Useful tools for application development
Workshops training
Preventive maintenance
Minimize downtime thanks to our service hotline

Accessories

Options

Nano Spray Dryer B-90 Basic

For for aqueous solutions.

Nano Spray Dryer B-90 Advanced

Ready to work with organic solvents in combination with the Inert Loop B-295; includes complete set-up, solvent resistant tubings, inert gas regulation and oxygen safety measure.

Aspirator

Corrosion resistant aspirator to generate the drying gas in open mode or to recirculate the gas in closed mode.

Expert Advice

Do we have the possibility to spray with organic solvents?

Read more about Do we have the possibility to spray with organic solvents?

With the Mini Spray Dryer B-290 or with the Nano Spray Dryer B-90 with the Inert Loop B-295 it is possible to spray with organic solvents without risk of explosion, because the system works under inert conditions.

How can I control the outlet temperature?

Read more about How can I control the outlet temperature?

The outlet temperature is depending on the parameters inlet temperature, sample feed rate, sample concentration and aspirator rate. A change in one of those parameters will either cause the outlet temperature increase or decrease.

What is the highest possible viscosity of a sample?

Read more about What is the highest possible viscosity of a sample?

The limiting factor is the peristaltic pump. So the sample still has to be pumpable. This will be possible with a viscosity up to 300 cps with the Mini Spray Dryer B-290 or 10 cps with the Nano Spray Dryer B-90.

What is the main difference between Nano Spray Dryer B-90 and Mini Spray Dryer B-290?

Read more about What is the main difference between Nano Spray Dryer B-90 and Mini Spray Dryer B-290?

Major differences: B-90 for smaller sample quantities (mL samples, mg powder amounts), higher yields up to 90% and smaller particle sizes (submicron) B-290 is the classical spray dryer for medium laboratory sample quantities at a wide range of applications (also viscous substances and fruit juices possible). Its scale-up is more straigthforward.

Is there any effect of the electrostatic field at the collector electrode on protein stability?

Read more about Is there any effect of the electrostatic field at the collector electrode on protein stability?

So far we didn’t see any negative effects. The particle charge is released after deposition on the collecting metal tube electrode. We have beta testers that sprayed proteins, which remained active after the spray drying process. We will study this question more detailed during the beta-test phase. First tests with model proteins revealed marginal effects on protein stability or activity.

What are the effects on particles from the electrostatic particle collector?

Read more about What are the effects on particles from the electrostatic particle collector?

The particles will receive electrostatic charges which will remain on the particle surface. The larger particles carry a higher charge and will gather in the upper half of the electrode. Smaller particles carry a lower charge and will accumulate in the lower half of the electrode. Therefore BUCHI developed an efficient particle size separator!

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