Spray-drying was shown to be a rapid, continuous, cost-effective, reproducible and scalable process for the production of dry powders from a liquid. Moreover, in the recent years, spray drying was identified by the pharmaceutical industry as a suitable method to produce protein particles used in pulmonary, nasal and oral delivery.
Due to its property, bovine serum albumin (BSA) has many applications in life science disciplines, such as cell culture, in-vitro diagnostics, human and veterinary pharmaceuticals, molecular biology, serology and general research. It is also very well characterized and often used as a model protein in numerous biochemical applications.
The possibility to use the Nano Spray Dryer B-90 HP to produce protein sub-micron particles will be investigated here, using BSA as a model protein. The influence of the BSA concentration and pH on particles formation will also be studied.