Aplicaciones

Spray Drying of Oxyhemoglobin

Spray drying has been used to prepare Oxyhemoglobin (OxyHb) nanoparticles, which are useful in drug delivery applications. The process involves the formation of OxyHb nanoparticles by spray drying a solution containing OxyHb and a biodegradable polymer such as poly(lactide-co-glycolide) (PLGA). Spray drying leads to the formation of a dry powder, which can be easily stored and transported.

OxyHb nanoparticles are being investigated for their use in targeted drug delivery systems, as they can be used to deliver drugs to specific tissues in the body. They can also be used to enhance the therapeutic efficacy of drugs, reduce their side effects and improve their bioavailability.

OxyHb nanoparticles have also been studied for their use in oxygen carriers for blood substitutes. Spray drying has been used to prepare OxyHb nanoparticles coated with a biocompatible polymer, which can be used as oxygen carriers in the treatment of anemia and other blood-related disorders.

Please see the application note No. 596 for starting parameters and some results.

Spray Drying of Passion flower

Passion flower (Passiflora incarnata) is a plant known for its sedative and anxiolytic properties, making it useful in the treatment of anxiety and sleep disorders. Spray drying has been used to produce passion flower extract powders, which can be used to make supplements, herbal remedies, and functional foods.

The spray drying process involves atomizing a solution or suspension of passion flower extract into a hot gas stream, which rapidly evaporates the solvent, leaving behind a dry powder containing the passion flower extract.

Spray-dried passion flower extract powders have been shown to have improved stability, longer shelf life, and enhanced bioavailability compared to traditional liquid extracts. They can be used in a range of applications, including the development of dietary supplements, herbal remedies, and functional foods.

Overall, spray drying of passion flower extract offers numerous benefits and has a wide range of potential applications in the herbal and dietary supplement industries. Its versatility and adaptability make it a valuable tool for the development of new and innovative products with improved properties and health benefits.

Please see the application note No. 601 for starting parameters and some results.

Production of alginate beads using Encapsulator Flow Vibration Nozzle

Short test compilation of alginate beads produced with vibrated concentric air system. 4% alginate solution (low viscosity grade) is prilled with the new concentric nozzle system, where air or another gas is blown through the shell nozzle. The inner liquid is vibrated. The air flow rate, the liquid flow rate and the vibration is adjusted so that a droplet chain is visible in the light of the stroboscope lamp.

Spray Drying of Oxaprozin

Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve inflammation, swelling, and stiffness in the body. Spray drying is a technique that has been used to formulate oxaprozin into various forms such as powders, capsules, and tablets. The process involves atomizing a liquid formulation into small droplets, which are then rapidly dried to form a fine powder. This results in an increase in surface area, which enhances dissolution and bioavailability of the drug.

Spray-dried oxaprozin has been used for various purposes such as improving drug stability, solubility, and oral bioavailability. The technique has also been used to formulate sustained-release formulations of oxaprozin, which can provide controlled drug delivery over an extended period. In addition, spray-dried oxaprozin has been incorporated into polymeric nanoparticles, which can improve drug targeting and reduce toxicity.

Overall, the spray drying of oxaprozin has numerous potential applications in the pharmaceutical industry, including drug formulation, drug delivery, and improved therapeutic efficacy.

Please see the application note No. 595 for starting parameters and some results.

Spray Drying of Peach oil

Peach oil is a natural oil extracted from the kernels of peaches and has various applications in the cosmetic and food industries. Spray drying is a common method used to convert peach oil into a dry powder or particles for improved handling and storage.

The spray drying process involves atomizing a peach oil solution or suspension into a hot gas stream, which rapidly evaporates the solvent, leaving behind a dry powder or particles containing peach oil. The size and shape of the particles can be controlled by adjusting the spray drying conditions, such as the feed rate, drying temperature, and gas flow rate.

Spray-dried peach oil particles have numerous applications in the cosmetic industry. The dry powder can be used in formulations for skin and hair care products, such as lotions, creams, shampoos, and conditioners. In the food industry, spray-dried peach oil particles can be added to dry mixes for baked goods, desserts, and snacks to enhance their flavor and nutritional value.

Overall, spray drying of peach oil is a versatile and efficient process that offers various benefits and has a wide range of applications. It provides a stable, free-flowing powder or particles that are easier to handle and store, making it a valuable tool for the development of new and innovative products in the cosmetic and food industries.

Please see the application note No. 602 for starting parameters and some results.

Preparation of SiO2 agglomerated particles

Nowadays, nanoparticles are attracting a lot of attention in several industry applications such as ceramic material, atmospheric plasma spray (APS) coating, drug formulation or drug delivery system. Their small size makes them challenging to handle and can represent a risk for the health of the personnel using such powders. Agglomerating the nanoparticles is necessary to overcome the previously mentioned issue.Free-flowing, spherical particles with uniform morphology and narrow size distribution are highly desirable for many applications and can easily be obtained by spray drying. For applications in ceramic material or drug formulation for example, a compression of the agglomerate material is necessary to obtain the final product. The properties of the agglomerated material will largely determine the compaction behavior of the powder and the uniformity of the final product. Spray drying is an established method to produce granulated material by converting a liquid (i.e. solution, emulsion or suspension) into solid spherical particles with precise specifications.If the used suspension consists of nanoparticles, the resulting agglomerated product comprises nanoparticles forming a nanostructured powder in the sub-micrometer / micrometer size range. Through this approach, the properties of nanoscale particles are preserved into micrometer scale particles which are easier and safer to handle.Due to its chemical and physical properties, silica is an advanced material widely used in a variety of applications such as ceramic production, drug formulation or drug delivery. Here, silica was chosen as a model suspension material to invest igate the feasibility to agglomerate nanoparticles using the Nano Spray Dryer B-90 HP.

Nitrogen Determination in Reference Substances

In order to verify the BUCHI Digest System K-437 or the Digest Automat K-438 in combination with the KjelMaster K-375 with KjelSampler K-376, the nitrogen content of different reference substances is determined according to the classical Kjeldahl method. All recoveries of the samples should be within the specification of 98-102%.

Determinación del contenido de nitrógeno no proteico en la leche

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Spray Drying of Plant Extracts for Liquor

Spray drying of plant extracts for liquor is a popular technique used in the food and beverage industry to improve the shelf life of natural extracts and enhance their functionality. The process involves atomizing a solution or suspension of plant extracts into a hot gas stream, where the solvent evaporates, leaving behind a fine powder.

The plant extracts used for liquor are typically rich in antioxidants, flavor compounds, and other bioactive ingredients that can provide health benefits and improve the sensory properties of beverages. Some common plant extracts used in liquor production include herbs, spices, fruits, and vegetables. Spray drying allows manufacturers to preserve the potency and flavor of these extracts while improving their solubility and stability.

Spray-dried plant extracts are used in the production of various alcoholic beverages, including beer, wine, and spirits. They are also used in non-alcoholic beverages such as soft drinks and functional beverages. Additionally, they are used as ingredients in food products like confectionery, bakery, and snack foods.

Please see the application note No. 611 for starting parameters and some results.

Novel k-carrageenan and k-carrageenan-alginate beads

Alginate and carrageenan are biocompatible polymers abundant in nature that could be used as matrix material for gel beads. These novel beads may serve for a wide variety of applications, such as enzyme immobilization.Aim of this application is to produce k-carrageenan as well as k-carrageenan-alginate beads with the Encapsulator B-390. The Encapsulator B-390 is a laboratory instrument applied in chemistry, pharmaceutical, food and biotechnology field to produce spherical and homogeneous beads.

Pressurized Water Extraction of polyphenols and essential oils in thyme

The extraction of valuable ingredients in thyme is the focus of different extraction techniques. The most commonly used technologies are liquid-solid-, pressurized liquid-, supercritical fluid- and pressurized water extraction. A fast and reliable method for the extraction of thyme is introduced below. The sample is extracted using the SpeedExtractor E-914 and analyzed to determine the amount of polyphenols.

Spray Drying of Probiotic Milk

Spray drying is a commonly used technique in the food industry to produce dry powders from liquid solutions or suspensions. In recent years, spray drying has been utilized in the production of probiotic milk powders, which offer numerous benefits and advantages over conventional methods of probiotic milk production.

Spray drying of probiotic milk allows for the production of powders with improved stability, longer shelf life, and enhanced bioavailability. The process involves atomizing the milk and probiotic culture into a hot gas stream, which rapidly evaporates the water, leaving behind a dry powder that contains the probiotic microorganisms.

Applications of spray-dried probiotic milk powders include the development of functional food products, such as yogurt, cheese, and infant formula, which can provide a range of health benefits. Probiotic milk powders can also be used in the development of dietary supplements and nutraceuticals.

Overall, spray drying of probiotic milk offers numerous benefits and has a wide range of potential applications in the food industry. Its versatility and adaptability make it a valuable tool for the development of new and innovative functional food products with improved properties and health benefits.

Please see the application note No. 629 for starting parameters and some results.

Spray Drying of Norfenefrine-HCl

Spray drying of Norfenefrine-HCl is a process that converts a liquid solution into a dry, powdered form. Norfenefrine-HCl is a sympathomimetic drug used in the treatment of hypotension (low blood pressure). It works by stimulating alpha-adrenergic receptors, leading to an increase in peripheral vascular resistance and blood pressure. Spray drying can be used to improve the solubility and bioavailability of the drug by reducing particle size and increasing surface area. The resulting powder is easy to handle, store, and transport, and can be formulated into various dosage forms such as tablets, capsules, or injectables.

Spray-dried Norfenefrine-HCl has several applications in the pharmaceutical industry, including the development of sustained-release dosage forms, nasal sprays, and inhalation formulations. It is also used in the preparation of parenteral solutions and for the treatment of shock, heart failure, and other circulatory disorders. Spray drying technology provides a cost-effective and efficient method for producing high-quality Norfenefrine-HCl powder with enhanced physicochemical properties for various pharmaceutical applications.

Please see the application note No. 588 for starting parameters, formulations and some results.

Spray Drying of Polyacrylic acid

Polyacrylic acid (PAA) is a synthetic polymer used in a wide range of industrial and biomedical applications, including drug delivery, wound dressings, and superabsorbent materials. Spray drying has been used to produce PAA particles in various forms, such as nanoparticles, microparticles, and aerogels.

The spray drying process involves atomizing a solution or suspension of PAA into a hot gas stream, which rapidly evaporates the solvent, leaving behind a dry powder containing PAA particles. The size, shape, and properties of the particles can be controlled by adjusting the spray drying conditions, such as the feed rate, drying temperature, and gas flow rate.

Applications of spray-dried PAA particles include drug delivery systems, wound dressings, and superabsorbent materials. The PAA particles can be functionalized with various drugs, biomolecules, or functional groups to enhance their properties and performance.

Overall, spray drying of PAA particles offers numerous benefits and has a wide range of potential applications in the industrial and biomedical fields. Its versatility and adaptability make it a valuable tool for the development of new and innovative materials with improved properties and performance.

Please see the application note No. 617 for starting parameters and some results.

Pre-Extraction and Extraction of Hypericin in St. John's Wort (Hypericum perforatum) using the SpeedExtractor E-916

In herbal medicine St. John's Wort herb and capsules with dry extract are widely used for the treatment of depressions. In this products hypericin is determined for quality reasons. The determination of the total amount of hypericin can be done by extraction and photometric quantification at 590 nm. The quantification by photometry is interfered by co-extracted chlorophyll. Removal of the interfering chlorophyll was achieved by a pre-extraction with dichloromethane. The remainings were then extracted with methanol to quantify hypericin.

Production of hard fat capsules

Producing cellulose sulphate microcapsules

PCB determination in sediment

Polychlorinated biphenyls (PCBs) are a class of organic compounds based on biphenyl substituted with 1-10 chlorine atoms. They are toxic, persistent and bioaccumulate in terrestrial and aquatic biosystems and are ubiquitous in the environment. This Application Note describes the extraction and determination of PCBs in a dried sediment SETOC sample according to EPA 3541. The sample was extracted with the UniversalExtractor E-800 in the Soxhlet warm mode. 

Spray Drying of Pigment

Spray drying is a commonly used technique for the production of pigments in various industries. Pigments are used in a wide range of applications, including paints, inks, cosmetics, and plastics. Spray drying of pigments involves the production of fine powders by converting liquid pigments into solid particles using a spray dryer. The process involves atomizing the liquid pigment into small droplets that are rapidly dried in a hot gas stream, resulting in the formation of fine powder particles.

The advantages of spray drying for pigment production include improved dispersion and flow properties, reduced caking and agglomeration, and increased shelf life. The process also allows for precise control of particle size and morphology, which can affect the properties and performance of the final product.

Some examples of pigments produced using spray drying include titanium dioxide, iron oxide, and carbon black. These pigments are used in a wide range of applications, including automotive coatings, plastic colorants, and inkjet inks.

Please see the application note No. 610 for starting parameters and some results.

Production of Ca-Alginate Beads