Spray Drying of Fenofibrate
Spray Drying of Fenofibrate with the Mini Spray Dryer B-290
Fenofibrate is a widely used lipid-lowering drug used to treat high cholesterol and triglyceride levels in the blood. Spray drying is a promising technique for producing dry powders of fenofibrate formulations that can improve the stability and handling of the drug.
Spray drying of fenofibrate powders requires careful optimization of several parameters, such as the type and concentration of the excipient, the drying temperature, and the feed rate. The final powder properties such as particle size, morphology, and purity depend on these parameters.
The applications of spray-dried fenofibrate powder are diverse and include the production of solid oral dosage forms, such as tablets and capsules. The use of spray-dried fenofibrate powder can improve the bioactivity, stability, and solubility of the drug, enhance its therapeutic efficacy, and provide a more convenient form of administration.
Overall, spray drying of fenofibrate powder is an important process in the pharmaceutical industry, providing a stable and versatile powder form of the drug with improved functional properties that can be applied in various drug delivery applications.
Please see the application note No. 510 for starting parameters, formulations and some results.
