EN

Purification

“Active Pharmaceutical Ingredients” (APIs) are generated by organic synthesis, biochemical process or extraction. The end result must always be further concentrated and purified. BUCHI chromatography solutions allow the purification of compounds from a few milligrams up to several hundred grams. Our solutions cover the complete sample range and allow simple up-scale from lab to production scale.

  Flash chromato-
graphy
Medium Pressure Liquid Chromato-
graphy
Preparative HPLC
 
Maximum pressure (bar/psi) 15 / 200 50 / 725 120 / 1700
Maximum flow rate (mL/min) 200 250 200
UV detection 200 – 500 nm 200 – 840 nm 200 – 500 nm
ELSD Integrated or optional Optional Integrated
Application overview Applications

 

The samples complexity, purity or polarity as well as the amount to purify dictate the choice of the column. The type of columns selected must not only allow to perform the separation, but also be compatible with the economical requirements. BUCHI has a column for almost any flash chromatography application: prepacked or empty cartridges, glass columns allow the purification of compounds from a few milligrams up to several hundred grams.

  Flash cartridges Glass columns Prep HPLC columns
 
Size From 4 g up to 1500 g ID (mm): 15, 26, 36, 49, 70, 100 ID (mm): 10, 20, 30, 50
Length (mm): 100, 230, 460, 920 Length (mm): 150, 250
Packing material Si, C18, Diol, Amino - Si, C18
Particle size 20, 40 µm - 10, 15 µm