Poly-lactic acid (PLA) microbeads with spherical shape having a diameter around 550 μm were produced using a three-step process. Firstly, uniform PLA droplets (dissolved in DCM) were stabilized in a calcium-alginate shell. Then the organic solvent was evaporated and finally, the PLA microspheres were recovered by dissolution of the alginate shell in tri-sodium citrate solution. Active pharmaceutical ingredients (APIs) could be embedded in the PLA matrix to extend the shelf live, increase the bioavailability as well as retarding its release.
Production of uniform poly-lactic acid beads