“Active Pharmaceutical Ingredients” (APIs) are generated by organic synthesis, biochemical process or extraction. The end result must always be further concentrated and purified. BUCHI chromatography solutions allow the purification of compounds from a few milligrams up to several hundred grams. Our solutions cover the complete sample range and allow simple up-scale from lab to production scale.

	Flash Chromato- graphy	Prep HPLC Chromatography	Flash & Prep HPLC Chromatography
Maximum pressure (bar/psi)	50 / 725	300 / 4350	flash: 50/725 prep HPLC: 300 / 4350
Maximum flow rate (mL/min)	250	100	flash: 250 prep HPLC:100
UV-Vis detection	200 – 400 nm optional Vis (400-800nm)	200 – 800 nm	200 – 800 nm
ELS detector	no / Integrated	no / Integrated	Integrated
Application overview	Applications

The samples complexity, purity or polarity as well as the amount to purify dictate the choice of the column. The type of columns selected must not only allow to perform the separation, but also be compatible with the economical requirements. BUCHI has a column for almost any flash chromatography application: prepacked or empty cartridges, glass columns allow the purification of compounds from a few milligrams up to several hundred grams.

	Flash cartridges	Glass columns	Prep columns
Size	4 to 3200 g	ID (mm): 15, 26, 36, 49, 70, 100	ID (mm): 4.6 to 70
		Length (mm): 100, 230, 460, 920	Length (mm): 150, 250
Packing material	Si, C18, C18WP, Amino, Diol, Alumina	up to customer	Si, C18, C18AQ, C4
Particle size	15, 20, 30, 40, 50, 60 µm	up to customer	5, 10, 15 µm