Solution «Spray Drying Medium» (2 – 25 μm)

Laboratory Spray Drying at high throughput with maximum possibilities

You want to benefit from an ingenious technology of spray drying for your demanding product development process. We offer the market leading solution with the most possibilities in applications to reduce development time

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Overview

Benefits

Versatile

Spray drying, spray chilling and microencapsulation with one product.
Processing of organic solvent based samples in combination with the Inert Loop B-295
Processing of organic solvents and water mixtures based samples in combination with the Inert Loop B-295 and the Dehumidifier B-296

Straightforward

Free access to more than 400 reproducible applications on our database
Small sample amounts facilitate formulation and parameter optimization
Quick and easy operation
Scale-up your process to high product volumes

Safe

Explosion-free handling of organic solvents due to safety equipment
User protection due to lamella safety curtain
Safe handling of alkaline or acidic samples

Voice of the customer

“We have successfully developed our product for the above application using the BUCHI Mini Spray Dryer B-290, and now we are into the process of commercializing this product for the open market”

Dr. Nalini Vemuri, Vice President (R&D)

Lifecare Innovations Private Limited, India

Scope

Service & Support

Free online application database
Customized application support
Authorized IQ / OQ documentation
Useful tools for application development
Training workshops
Preventive maintenance
Minimize downtime thanks to our service hotline

Applied products

Mini Spray Dryer B-290

Dehumidifier B-296

Inert Loop B-295

Accessories

Options

Mini Spray Dryer B-290 Advanced

Designed to handle pure organic solvents or mixtures with water safely. Can be combined with the Inert Loop B-295 and the Dehumidifier B-296.

Mini Spray Dryer B-290 Acid Proof

Designed to handle acidic or basic samples.

Outlet filter

Outlet filter with a polyesterdeep bed filter and display of the pressure drop. Provides optimal protection for the aspirator and whilst permitting cleaning of the aspirator.

Spray Chilling

Liquifying bath, incl. heater, temperature probe and metering valve. Temperature range 20–150 °C, Batch volume 300 ml. Reverse compatibility for installed B-290 upon request.

Nozzle

The three-fluid nozzle for the Mini Spray Dryer B-290 allows handling immiscible samples or allows in some cases to produce core shell capsules.

Expert Advice

Do we have the possibility to spray with organic solvents?

Read more about Do we have the possibility to spray with organic solvents?

With the Mini Spray Dryer B-290 or with the Nano Spray Dryer B-90 with the Inert Loop B-295 it is possible to spray with organic solvents without risk of explosion, because the system works under inert conditions.

How can I control the outlet temperature?

Read more about How can I control the outlet temperature?

The outlet temperature is depending on the parameters inlet temperature, sample feed rate, sample concentration and aspirator rate. A change in one of those parameters will either cause the outlet temperature increase or decrease.

What is the highest possible viscosity of a sample?

Read more about What is the highest possible viscosity of a sample?

The limiting factor is the peristaltic pump. So the sample still has to be pumpable. This will be possible with a viscosity up to 300 cps with the Mini Spray Dryer B-290 or 10 cps with the Nano Spray Dryer B-90.

What is the main difference between Nano Spray Dryer B-90 and Mini Spray Dryer B-290?

Read more about What is the main difference between Nano Spray Dryer B-90 and Mini Spray Dryer B-290?

Major differences: B-90 for smaller sample quantities (mL samples, mg powder amounts), higher yields up to 90% and smaller particle sizes (submicron) B-290 is the classical spray dryer for medium laboratory sample quantities at a wide range of applications (also viscous substances and fruit juices possible). Its scale-up is more straigthforward.

Is there any effect of the electrostatic field at the collector electrode on protein stability?

Read more about Is there any effect of the electrostatic field at the collector electrode on protein stability?

So far we didn’t see any negative effects. The particle charge is released after deposition on the collecting metal tube electrode. We have beta testers that sprayed proteins, which remained active after the spray drying process. We will study this question more detailed during the beta-test phase. First tests with model proteins revealed marginal effects on protein stability or activity.

What are the effects on particles from the electrostatic particle collector?

Read more about What are the effects on particles from the electrostatic particle collector?

The particles will receive electrostatic charges which will remain on the particle surface. The larger particles carry a higher charge and will gather in the upper half of the electrode. Smaller particles carry a lower charge and will accumulate in the lower half of the electrode. Therefore BUCHI developed an efficient particle size separator!

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