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Microencapsulation

Generate added value

Encapsulation is the immobilization of active ingredients in a matrix or a core-shell capsule which can range from a few hundred nano-meters up to a several millimeters in size. The matrix or shell is used as a retention network and a protection shield for the active ingredient as well as a barrier through which only specific compounds can diffuse.

The six main benefits for encapsulation a material:

  • Protection from conditions such as heat, moisture, oxygen and will prolong shelf-life
  • Controlled or sustained release to help develop new deliver mechanisms
  • Targeting to specific sites direct delivery to the site where it is required.
  • To enable the encapsulated material to act as extraction aides for product removal.
  • Improved flow properties by converting a liquid into a solid particle which improves handling, usage and storage.
  • Improved organoleptic properties to mask its unpleasant taste and/or small and improve its visual appearance as well as its texture.

These benefits can give your product added value for application in several industries such pharmaceutical, medical & biotech, chemical, agricultural, food & feed, personal care products, cosmetics, etc.

 

 

 

 

Encapsulation technologies

BUCHI offers you two main encapsulation technologies for you to create innovative products in your daily R&D work.  These technologies allow you to create a wide range of particle types (wet, dry, powders, beads and capsules) and particle sizes (from nano- to millimeter scale).

 
  Spray Drying Prilling by vibration
Particles type Dry homogenous or matrix particles Liquid core beads or capsules (wet) (possible to dry after)
Excipients
(= shell material)
Sugars, starch, cellulose, gum, polymers, wax, proteins (or no excipients) Polymers, alginate, gelatin, wax, gum, proteins, cellulose, whey
Advantages ∙Continuous process
∙Short process time
∙Low cost at industrial scale
∙Protection of core material

∙Particle hardening in cooling or polymerization bath

∙Short process time
∙Suitable for sterile application

Process conditions Mild drying conditions Extremely gentle
Particle size distribution Broad Narrow
Particles size Controllable particle size and morphology
(0.3 – 60 μm)
Selectable particle size
(100 – 2000 μm)
 

 

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